| http://purl.uniprot.org/citations/33658226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33658226 | http://www.w3.org/2000/01/rdf-schema#comment | "Groucho-related genes (GRGs) are transcriptional co-repressors that are crucial for many developmental processes. Several essential pancreatic transcription factors are capable of interacting with GRGs; however, the in vivo role of GRG-mediated transcriptional repression in pancreas development is still not well understood. In this study, we used complex mouse genetics and transcriptomic analyses to determine that GRG3 is essential for β cell development, and in the absence of Grg3 there is compensatory upregulation of Grg4Grg3/4 double mutant mice have severe dysregulation of the pancreas gene program with ectopic expression of canonical liver genes and Foxa1, a master regulator of the liver program. Neurod1, an essential β cell transcription factor and predicted target of Foxa1, becomes downregulated in Grg3/4 mutants, resulting in reduced β cell proliferation, hyperglycemia, and early lethality. These findings uncover novel functions of GRG-mediated repression during pancreas development."xsd:string |
| http://purl.uniprot.org/citations/33658226 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.192401"xsd:string |
| http://purl.uniprot.org/citations/33658226 | http://purl.uniprot.org/core/author | "Paul A."xsd:string |
| http://purl.uniprot.org/citations/33658226 | http://purl.uniprot.org/core/author | "Singer R.A."xsd:string |
| http://purl.uniprot.org/citations/33658226 | http://purl.uniprot.org/core/author | "Sussel L."xsd:string |
| http://purl.uniprot.org/citations/33658226 | http://purl.uniprot.org/core/author | "Narayana A."xsd:string |
| http://purl.uniprot.org/citations/33658226 | http://purl.uniprot.org/core/author | "Theis A."xsd:string |
| http://purl.uniprot.org/citations/33658226 | http://purl.uniprot.org/core/author | "Garofalo D."xsd:string |
| http://purl.uniprot.org/citations/33658226 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33658226 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/33658226 | http://purl.uniprot.org/core/pages | "dev192401"xsd:string |
| http://purl.uniprot.org/citations/33658226 | http://purl.uniprot.org/core/title | "Groucho co-repressor proteins regulate beta cell development and proliferation by repressing pii>Foxa1pi/i> in the developing mouse pancreas."xsd:string |
| http://purl.uniprot.org/citations/33658226 | http://purl.uniprot.org/core/volume | "148"xsd:string |
| http://purl.uniprot.org/citations/33658226 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33658226 |
| http://purl.uniprot.org/citations/33658226 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33658226 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVC9-mappedCitation-33658226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33658226 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQV9-mappedCitation-33658226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33658226 |
| http://purl.uniprot.org/uniprot/#_D3Z0X0-mappedCitation-33658226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33658226 |
| http://purl.uniprot.org/uniprot/#_D3Z1A4-mappedCitation-33658226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33658226 |
| http://purl.uniprot.org/uniprot/#_D3Z2J7-mappedCitation-33658226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33658226 |
| http://purl.uniprot.org/uniprot/#_D3Z595-mappedCitation-33658226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33658226 |
| http://purl.uniprot.org/uniprot/#_D3Z596-mappedCitation-33658226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33658226 |
| http://purl.uniprot.org/uniprot/#_E0CXS2-mappedCitation-33658226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33658226 |
| http://purl.uniprot.org/uniprot/#_E0CXS9-mappedCitation-33658226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33658226 |