| http://purl.uniprot.org/citations/33670444 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33670444 | http://www.w3.org/2000/01/rdf-schema#comment | "Sialic acid-binding immunoglobulin-like lectins (Siglecs) are involved in various immune cell-mediated diseases. Their role in cancer is poorly investigated, and research focusses on Siglec-expression on immune cells interacting with tumor cells. This study evaluates the role of Siglec-8 in breast cancer (BC). Siglec-8 expression was analyzed immunohistochemically on 235 primary BC cases and was correlated with clinical and pathological parameters and outcome. Cell culture experiments were performed with various BC cell lines. Siglec-8 was expressed in 215 BC cases and expression was lowest in triple-negative BC. It correlated with estrogen receptor-status, grading and the prognostic factors galectin (Gal)-7 and tumor-associated mucin-1 (TA-MUC1). However, Gal-7 and TA-MUC1 were only prognosticators for clinical outcome in the cohort expressing high (Immunoreactivity score IRS > 3) Siglec-8 levels but not in the low-expressing cohort. Siglec-8 knockdown led to a significantly reduced Gal-7 expression in MCF7 cells. All BC cell lines expressed low Siglec-8-levels, that could be elevated in MCF7 by Peroxisome proliferator-activated receptor (PPARγ)-stimulation. This study demonstrates that Siglec-8 is expressed in BC cells and correlates with known clinical and prognostic parameters. It is probably associated with Gal-7 and TA-MUC1 and might be regulated via PPARγ. Further analyses focusing on functional associations will clarify Siglec-8's eligibility as a possible therapeutic target."xsd:string |
| http://purl.uniprot.org/citations/33670444 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms22042000"xsd:string |
| http://purl.uniprot.org/citations/33670444 | http://purl.uniprot.org/core/author | "Kuhn C."xsd:string |
| http://purl.uniprot.org/citations/33670444 | http://purl.uniprot.org/core/author | "Meister S."xsd:string |
| http://purl.uniprot.org/citations/33670444 | http://purl.uniprot.org/core/author | "Hester A."xsd:string |
| http://purl.uniprot.org/citations/33670444 | http://purl.uniprot.org/core/author | "Mayr D."xsd:string |
| http://purl.uniprot.org/citations/33670444 | http://purl.uniprot.org/core/author | "Mahner S."xsd:string |
| http://purl.uniprot.org/citations/33670444 | http://purl.uniprot.org/core/author | "Ditsch N."xsd:string |
| http://purl.uniprot.org/citations/33670444 | http://purl.uniprot.org/core/author | "Degenhardt T."xsd:string |
| http://purl.uniprot.org/citations/33670444 | http://purl.uniprot.org/core/author | "Jeschke U."xsd:string |
| http://purl.uniprot.org/citations/33670444 | http://purl.uniprot.org/core/author | "Rahmeh M."xsd:string |
| http://purl.uniprot.org/citations/33670444 | http://purl.uniprot.org/core/author | "Kolben T."xsd:string |
| http://purl.uniprot.org/citations/33670444 | http://purl.uniprot.org/core/author | "Czogalla B."xsd:string |
| http://purl.uniprot.org/citations/33670444 | http://purl.uniprot.org/core/author | "Schmoeckel E."xsd:string |
| http://purl.uniprot.org/citations/33670444 | http://purl.uniprot.org/core/author | "Trebo A."xsd:string |
| http://purl.uniprot.org/citations/33670444 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33670444 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/33670444 | http://purl.uniprot.org/core/pages | "2000"xsd:string |
| http://purl.uniprot.org/citations/33670444 | http://purl.uniprot.org/core/title | "First Evidence for a Role of Siglec-8 in Breast Cancer."xsd:string |
| http://purl.uniprot.org/citations/33670444 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/33670444 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33670444 |
| http://purl.uniprot.org/citations/33670444 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33670444 |
| http://purl.uniprot.org/uniprot/#_C9JT30-mappedCitation-33670444 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33670444 |
| http://purl.uniprot.org/uniprot/#_Q9NYZ4-mappedCitation-33670444 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33670444 |