| http://purl.uniprot.org/citations/33672422 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33672422 | http://www.w3.org/2000/01/rdf-schema#comment | "Melanoma comprises <5% of cutaneous malignancies, yet it causes a significant proportion of skin cancer-related deaths worldwide. While new therapies for melanoma have been developed, not all patients respond well. Thus, further research is required to better predict patient outcomes. Using long-range nanopore sequencing, RT-qPCR, and RNA sequencing analyses, we examined the transcription of BARD1 splice isoforms in melanoma cell lines and patient tissue samples. Seventy-six BARD1 mRNA variants were identified in total, with several previously characterised isoforms (γ, φ, δ, ε, and η) contributing to a large proportion of the expressed transcripts. In addition, we identified four novel splice events, namely, Δ(E3_E9), ▼(i8), IVS10+131▼46, and IVS10▼176, occurring in various combinations in multiple transcripts. We found that short-read RNA-Seq analyses were limited in their ability to predict isoforms containing multiple non-contiguous splicing events, as compared to long-range nanopore sequencing. These studies suggest that further investigations into the functional significance of the identified BARD1 splice variants in melanoma are warranted."xsd:string |
| http://purl.uniprot.org/citations/33672422 | http://purl.org/dc/terms/identifier | "doi:10.3390/genes12020320"xsd:string |
| http://purl.uniprot.org/citations/33672422 | http://purl.uniprot.org/core/author | "Walker L.C."xsd:string |
| http://purl.uniprot.org/citations/33672422 | http://purl.uniprot.org/core/author | "Reid G."xsd:string |
| http://purl.uniprot.org/citations/33672422 | http://purl.uniprot.org/core/author | "Motwani J."xsd:string |
| http://purl.uniprot.org/citations/33672422 | http://purl.uniprot.org/core/author | "Ratajska M."xsd:string |
| http://purl.uniprot.org/citations/33672422 | http://purl.uniprot.org/core/author | "Eccles M.R."xsd:string |
| http://purl.uniprot.org/citations/33672422 | http://purl.uniprot.org/core/author | "Powell R.M."xsd:string |
| http://purl.uniprot.org/citations/33672422 | http://purl.uniprot.org/core/author | "Hossain S.M."xsd:string |
| http://purl.uniprot.org/citations/33672422 | http://purl.uniprot.org/core/author | "Rys J."xsd:string |
| http://purl.uniprot.org/citations/33672422 | http://purl.uniprot.org/core/author | "Harazin-Lechowska A."xsd:string |
| http://purl.uniprot.org/citations/33672422 | http://purl.uniprot.org/core/author | "Cybulska-Stopa B."xsd:string |
| http://purl.uniprot.org/citations/33672422 | http://purl.uniprot.org/core/author | "Lynch-Sutherland C.F."xsd:string |
| http://purl.uniprot.org/citations/33672422 | http://purl.uniprot.org/core/author | "Macaulay E.C."xsd:string |
| http://purl.uniprot.org/citations/33672422 | http://purl.uniprot.org/core/author | "McDougall L.I."xsd:string |
| http://purl.uniprot.org/citations/33672422 | http://purl.uniprot.org/core/author | "Wiggins G.A.R."xsd:string |
| http://purl.uniprot.org/citations/33672422 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33672422 | http://purl.uniprot.org/core/name | "Genes (Basel)"xsd:string |
| http://purl.uniprot.org/citations/33672422 | http://purl.uniprot.org/core/pages | "320"xsd:string |
| http://purl.uniprot.org/citations/33672422 | http://purl.uniprot.org/core/title | "Differential Expression of BARD1 Isoforms in Melanoma."xsd:string |
| http://purl.uniprot.org/citations/33672422 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/33672422 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33672422 |
| http://purl.uniprot.org/citations/33672422 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33672422 |
| http://purl.uniprot.org/uniprot/#_A0A087WZ19-mappedCitation-33672422 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33672422 |