| http://purl.uniprot.org/citations/33679793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33679793 | http://www.w3.org/2000/01/rdf-schema#comment | "Chemokine receptor-6 (CCR6) mediates immune cell recruitment to inflammatory sites and has cell type-specific effects on diet-induced atherosclerosis in mice. Previously we showed that loss of CCR6 in B cells resulted in loss of B cell-mediated atheroprotection, although the B cell subtype mediating this effect was unknown. Perivascular adipose tissue (PVAT) harbors high numbers of B cells including atheroprotective IgM secreting B-1 cells. Production of IgM antibodies is a major mechanism whereby B-1 cells limit atherosclerosis development. Yet whether CCR6 regulates B-1 cell number and production of IgM in the PVAT is unknown. In this present study, flow cytometry experiments demonstrated that both B-1 and B-2 cells express CCR6, albeit at a higher frequency in B-2 cells in both humans and mice. Nevertheless, B-2 cell numbers in peritoneal cavity (PerC), spleen, bone marrow and PVAT were no different in ApoE-/-CCR6-/- compared to ApoE-/-CCR6+/+ mice. In contrast, the numbers of atheroprotective IgM secreting B-1 cells were significantly lower in the PVAT of ApoE-/-CCR6-/- compared to ApoE-/-CCR6+/+ mice. Surprisingly, adoptive transfer (AT) of CD43- splenic B cells into B cell-deficient μMT-/-ApoE-/- mice repopulated the PerC with B-1 and B-2 cells and reduced atherosclerosis when transferred into ApoE-/-CCR6+/+sIgM-/- mice only when those cells expressed both CCR6 and sIgM. CCR6 expression on circulating human B cells in subjects with a high level of atherosclerosis in their coronary arteries was lower only in the putative human B-1 cells. These results provide evidence that B-1 cell CCR6 expression enhances B-1 cell number and IgM secretion in PVAT to provide atheroprotection in mice and suggest potential human relevance to our murine findings."xsd:string |
| http://purl.uniprot.org/citations/33679793 | http://purl.org/dc/terms/identifier | "doi:10.3389/fimmu.2021.636013"xsd:string |
| http://purl.uniprot.org/citations/33679793 | http://purl.uniprot.org/core/author | "Taylor A.M."xsd:string |
| http://purl.uniprot.org/citations/33679793 | http://purl.uniprot.org/core/author | "Marshall M.A."xsd:string |
| http://purl.uniprot.org/citations/33679793 | http://purl.uniprot.org/core/author | "Drago F."xsd:string |
| http://purl.uniprot.org/citations/33679793 | http://purl.uniprot.org/core/author | "McNamara C.A."xsd:string |
| http://purl.uniprot.org/citations/33679793 | http://purl.uniprot.org/core/author | "Perry H.M."xsd:string |
| http://purl.uniprot.org/citations/33679793 | http://purl.uniprot.org/core/author | "Bontha S.V."xsd:string |
| http://purl.uniprot.org/citations/33679793 | http://purl.uniprot.org/core/author | "Upadhye A."xsd:string |
| http://purl.uniprot.org/citations/33679793 | http://purl.uniprot.org/core/author | "McSkimming C."xsd:string |
| http://purl.uniprot.org/citations/33679793 | http://purl.uniprot.org/core/author | "Srikakulapu P."xsd:string |
| http://purl.uniprot.org/citations/33679793 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33679793 | http://purl.uniprot.org/core/name | "Front Immunol"xsd:string |
| http://purl.uniprot.org/citations/33679793 | http://purl.uniprot.org/core/pages | "636013"xsd:string |
| http://purl.uniprot.org/citations/33679793 | http://purl.uniprot.org/core/title | "Chemokine Receptor-6 Promotes B-1 Cell Trafficking to Perivascular Adipose Tissue, Local IgM Production and Atheroprotection."xsd:string |
| http://purl.uniprot.org/citations/33679793 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/33679793 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33679793 |
| http://purl.uniprot.org/citations/33679793 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33679793 |
| http://purl.uniprot.org/uniprot/#_O54689-mappedCitation-33679793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33679793 |
| http://purl.uniprot.org/uniprot/#_Q3U467-mappedCitation-33679793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33679793 |
| http://purl.uniprot.org/uniprot/#_Q542B6-mappedCitation-33679793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33679793 |
| http://purl.uniprot.org/uniprot/#_Q9R1V0-mappedCitation-33679793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33679793 |
| http://purl.uniprot.org/uniprot/O54689 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33679793 |
| http://purl.uniprot.org/uniprot/Q542B6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33679793 |