| http://purl.uniprot.org/citations/33683365 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33683365 | http://www.w3.org/2000/01/rdf-schema#comment | "Polyploidy is an integral part of development and is associated with cellular stress, aging, and pathological conditions. The endocycle, comprised of successive rounds of G and S phases without mitosis, is widely employed to produce polyploid cells in plants and animals. In Drosophila, maintenance of the endocycle is dependent on E2F-governed oscillations of Cyclin E (CycE)-Cdk2 activity, which is known to be largely regulated at the level of transcription. In this study, we report an additional level of E2F-dependent control of CycE-Cdk2 activity during the endocycle. Genetic experiments revealed that an alternative isoform of Drosophila de2f1, dE2F1b, regulates the expression of the p27CIP/KIP-like Cdk inhibitor Dacapo (Dap). We provide evidence showing that dE2F1b-dependent Dap expression in endocycling tissues is necessary for setting proper CycE-Cdk2 activity. Furthermore, we demonstrate that dE2F1b is required for proliferating cell nuclear antigen expression that establishes a negative feedback loop in S phase. Overall, our study reveals previously unappreciated E2F-dependent regulatory networks that are critical for the periodic transition between G and S phases during the endocycle."xsd:string |
| http://purl.uniprot.org/citations/33683365 | http://purl.org/dc/terms/identifier | "doi:10.1093/genetics/iyaa029"xsd:string |
| http://purl.uniprot.org/citations/33683365 | http://purl.uniprot.org/core/author | "Kim M."xsd:string |
| http://purl.uniprot.org/citations/33683365 | http://purl.uniprot.org/core/author | "Moon N.S."xsd:string |
| http://purl.uniprot.org/citations/33683365 | http://purl.uniprot.org/core/author | "Delos Santos K."xsd:string |
| http://purl.uniprot.org/citations/33683365 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33683365 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/33683365 | http://purl.uniprot.org/core/pages | "1-15"xsd:string |
| http://purl.uniprot.org/citations/33683365 | http://purl.uniprot.org/core/title | "Proper CycE-Cdk2 activity in endocycling tissues requires regulation of the cyclin-dependent kinase inhibitor Dacapo by dE2F1b in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/33683365 | http://purl.uniprot.org/core/volume | "217"xsd:string |
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