| http://purl.uniprot.org/citations/33706054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33706054 | http://www.w3.org/2000/01/rdf-schema#comment | "Diabetic coronary heart disease (DM-CHD) poses a major threat to the world. The newly described T cell subset-Th9 cells and related cytokine interleukin (IL)-9 play important roles in the pathogenesis of diabetes and atherosclerosis. B lymphocyte-induced maturation protein 1 (Blimp-1) has been indicated to negatively regulate Th9 development in allergic asthma, but its role in DM-CHD remains unclear. Hence, this study was designed to investigate the role of Blimp-1 in DM-CHD and to elucidate whether the mechanism was associated with regulation of Th9 cell differentiation. Our results showed that serum Blimp-1 mRNA level was decreased whereas proportion of Th9 cells (IL-9+ CD4+ T cells) and serum level of Th9-related IL-9 were increased in DM-CHD patients. Furthermore, serum Blimp-1 mRNA level was negatively correlated with IL-9 level in DM-CHD patients. Importantly, administration of lentiviruses expressing Blimp-1 (LV-Blimp-1) significantly inhibited Th9 cell differentiation and alleviated the severity of atherosclerotic lesions in the aorta and coronary artery, dyslipidemia, inflammation, vascular endothelial dysfunction, and oxidative stress in DM-CHD model rats. Collectively, Blimp-1 exerts a protective effect in DM-CHD rats and the mechanism might involve inhibition of Th9 cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/33706054 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.intimp.2021.107510"xsd:string |
| http://purl.uniprot.org/citations/33706054 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/33706054 | http://purl.uniprot.org/core/author | "Gao F."xsd:string |
| http://purl.uniprot.org/citations/33706054 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/33706054 | http://purl.uniprot.org/core/author | "Sun L."xsd:string |
| http://purl.uniprot.org/citations/33706054 | http://purl.uniprot.org/core/author | "Tang W."xsd:string |
| http://purl.uniprot.org/citations/33706054 | http://purl.uniprot.org/core/author | "Zheng J."xsd:string |
| http://purl.uniprot.org/citations/33706054 | http://purl.uniprot.org/core/author | "Zou J."xsd:string |
| http://purl.uniprot.org/citations/33706054 | http://purl.uniprot.org/core/author | "Bao Y."xsd:string |
| http://purl.uniprot.org/citations/33706054 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33706054 | http://purl.uniprot.org/core/name | "Int Immunopharmacol"xsd:string |
| http://purl.uniprot.org/citations/33706054 | http://purl.uniprot.org/core/pages | "107510"xsd:string |
| http://purl.uniprot.org/citations/33706054 | http://purl.uniprot.org/core/title | "Blimp-1 inhibits Th9 cell differentiation and attenuates diabetic coronary heart disease."xsd:string |
| http://purl.uniprot.org/citations/33706054 | http://purl.uniprot.org/core/volume | "95"xsd:string |
| http://purl.uniprot.org/citations/33706054 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33706054 |
| http://purl.uniprot.org/citations/33706054 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33706054 |
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| http://purl.uniprot.org/uniprot/#_O75626-mappedCitation-33706054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33706054 |
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