| http://purl.uniprot.org/citations/33711246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33711246 | http://www.w3.org/2000/01/rdf-schema#comment | "Raf-activating mutations are frequent in cancer. In the basal state, B-Raf is autoinhibited by its upstream Ras-binding domain (RBD) and cysteine-rich domain (RBD-CRD) interacting with its kinase domain (KD) and the 14-3-3 dimer. Our comprehensive molecular dynamics simulations explore two autoinhibition scenarios in the presence and absence of the 14-3-3 dimer. When present, the 14-3-3 interaction with B-Raf stabilizes the RBD-CRD-KD interaction, interfering with the KD dimerization. Raf's pSer365 removal fails to induce large disruption. RBD-CRD release promotes KD fluctuations and reorientation for dimerization, consistent with experimental data. In the absence of 14-3-3, our sampled B-Raf conformations suggest that RBD-CRD can block the KD dimerization surface. Our results suggest a B-Raf activation mechanism, whereby one KD monomer is donated by 14-3-3-free B-Raf KD and the other by 14-3-3-bound KD. This mechanism can lead to homo- and heterodimers. These autoinhibition scenarios can transform autoinhibited B-Raf monomers into active B-Raf dimers."xsd:string |
| http://purl.uniprot.org/citations/33711246 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2021.02.005"xsd:string |
| http://purl.uniprot.org/citations/33711246 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/33711246 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/33711246 | http://purl.uniprot.org/core/author | "Jang H."xsd:string |
| http://purl.uniprot.org/citations/33711246 | http://purl.uniprot.org/core/author | "Sacks D.B."xsd:string |
| http://purl.uniprot.org/citations/33711246 | http://purl.uniprot.org/core/author | "Nussinov R."xsd:string |
| http://purl.uniprot.org/citations/33711246 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33711246 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/33711246 | http://purl.uniprot.org/core/pages | "768-777.e2"xsd:string |
| http://purl.uniprot.org/citations/33711246 | http://purl.uniprot.org/core/title | "B-Raf autoinhibition in the presence and absence of 14-3-3."xsd:string |
| http://purl.uniprot.org/citations/33711246 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/33711246 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33711246 |
| http://purl.uniprot.org/citations/33711246 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33711246 |
| http://purl.uniprot.org/uniprot/#_P15056-mappedCitation-33711246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33711246 |
| http://purl.uniprot.org/uniprot/P15056 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33711246 |