| http://purl.uniprot.org/citations/33713958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33713958 | http://www.w3.org/2000/01/rdf-schema#comment | "Retinoic acid-inducible gene I (RIG-I) plays a critical role in the recognition of intracytoplasmic viral RNA. Upon binding to the RNA of invading viruses, the activated RIG-I translocates to mitochondria, where it recruits adapter protein MAVS, causing a series of signaling cascades. In this study, we demonstrated that Hsp70 binding protein 1 (HSPBP1) promotes RIG-I-mediated signal transduction. The overexpression of HSPBP1 can increase the stability of RIG-I protein by inhibiting its K48-linked ubiquitination, and promote the activation of IRF3 and the production of IFN-β induced by Sendai virus. Knockdown and knockout of HSPBP1 leads to down-regulation of virus-induced RIG-I expression, inhibits IRF3 activation, and reduces the production of IFNB1. These results indicate that HSPBP1 positively regulates the antiviral signal pathway induced by inhibiting the K48-linked ubiquitination of RIG-I."xsd:string |
| http://purl.uniprot.org/citations/33713958 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molimm.2021.03.002"xsd:string |
| http://purl.uniprot.org/citations/33713958 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/33713958 | http://purl.uniprot.org/core/author | "Li S.N."xsd:string |
| http://purl.uniprot.org/citations/33713958 | http://purl.uniprot.org/core/author | "Xie T."xsd:string |
| http://purl.uniprot.org/citations/33713958 | http://purl.uniprot.org/core/author | "Yang Y.X."xsd:string |
| http://purl.uniprot.org/citations/33713958 | http://purl.uniprot.org/core/author | "Xu L.G."xsd:string |
| http://purl.uniprot.org/citations/33713958 | http://purl.uniprot.org/core/author | "Ling T."xsd:string |
| http://purl.uniprot.org/citations/33713958 | http://purl.uniprot.org/core/author | "Huang J.P."xsd:string |
| http://purl.uniprot.org/citations/33713958 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33713958 | http://purl.uniprot.org/core/name | "Mol Immunol"xsd:string |
| http://purl.uniprot.org/citations/33713958 | http://purl.uniprot.org/core/pages | "62-71"xsd:string |
| http://purl.uniprot.org/citations/33713958 | http://purl.uniprot.org/core/title | "HSPBP1 facilitates cellular RLR-mediated antiviral response by inhibiting the K48-linked ubiquitination of RIG-I."xsd:string |
| http://purl.uniprot.org/citations/33713958 | http://purl.uniprot.org/core/volume | "134"xsd:string |
| http://purl.uniprot.org/citations/33713958 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33713958 |
| http://purl.uniprot.org/citations/33713958 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33713958 |
| http://purl.uniprot.org/uniprot/#_B3KN51-mappedCitation-33713958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33713958 |
| http://purl.uniprot.org/uniprot/#_B4DWT9-mappedCitation-33713958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33713958 |
| http://purl.uniprot.org/uniprot/#_B3KWW1-mappedCitation-33713958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33713958 |
| http://purl.uniprot.org/uniprot/#_Q3B797-mappedCitation-33713958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33713958 |
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| http://purl.uniprot.org/uniprot/#_O95786-mappedCitation-33713958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33713958 |
| http://purl.uniprot.org/uniprot/#_Q9NZL4-mappedCitation-33713958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33713958 |
| http://purl.uniprot.org/uniprot/B4DWT9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33713958 |