| http://purl.uniprot.org/citations/33723318 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33723318 | http://www.w3.org/2000/01/rdf-schema#comment | "Breast cancer is the leading cause of cancer death among women worldwide. Blocking a single signaling pathway is often an ineffective therapy, especially in the case of aggressive or drug-resistant tumors. Since we have previously described the mechanism involved in the crosstalk between Retinoic Acid system and protein kinase C (PKC) pathway, the rationale of our study was to evaluate the effect of combining all-trans-retinoic acid (ATRA) with a classical PCK inhibitor (Gö6976) in preclinical settings. Employing hormone-independent mammary cancer models, Gö6976 and ATRA combined treatment induced a synergistic reduction in proliferative potential that correlated with an increased apoptosis and RARs modulation towards an anti-oncogenic profile. Combined treatment also impairs growth, self-renewal and clonogenicity potential of cancer stem cells and reduced tumor growth, metastatic spread and cancer stem cells frequency in vivo. An in-silico analysis of "Kaplan-Meier plotter" database indicated that low PKCα together with high RARα mRNA expression is a favorable prognosis factor for hormone-independent breast cancer patients. Here we demonstrate that a classical PKC inhibitor potentiates ATRA antitumor effects also targeting cancer stem cells growth, self-renewal and frequency."xsd:string |
| http://purl.uniprot.org/citations/33723318 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-021-85344-w"xsd:string |
| http://purl.uniprot.org/citations/33723318 | http://purl.uniprot.org/core/author | "Edelstein A."xsd:string |
| http://purl.uniprot.org/citations/33723318 | http://purl.uniprot.org/core/author | "Motter A.N."xsd:string |
| http://purl.uniprot.org/citations/33723318 | http://purl.uniprot.org/core/author | "Peters M.G."xsd:string |
| http://purl.uniprot.org/citations/33723318 | http://purl.uniprot.org/core/author | "Urtreger A.J."xsd:string |
| http://purl.uniprot.org/citations/33723318 | http://purl.uniprot.org/core/author | "Todaro L.B."xsd:string |
| http://purl.uniprot.org/citations/33723318 | http://purl.uniprot.org/core/author | "Berardi D.E."xsd:string |
| http://purl.uniprot.org/citations/33723318 | http://purl.uniprot.org/core/author | "Diaz Bessone M.I."xsd:string |
| http://purl.uniprot.org/citations/33723318 | http://purl.uniprot.org/core/author | "Cirigliano S.M."xsd:string |
| http://purl.uniprot.org/citations/33723318 | http://purl.uniprot.org/core/author | "Amigo N."xsd:string |
| http://purl.uniprot.org/citations/33723318 | http://purl.uniprot.org/core/author | "Ariza Bareno L."xsd:string |
| http://purl.uniprot.org/citations/33723318 | http://purl.uniprot.org/core/author | "Canonero L."xsd:string |
| http://purl.uniprot.org/citations/33723318 | http://purl.uniprot.org/core/author | "Diament M."xsd:string |
| http://purl.uniprot.org/citations/33723318 | http://purl.uniprot.org/core/author | "Pelagatti M.L.N."xsd:string |
| http://purl.uniprot.org/citations/33723318 | http://purl.uniprot.org/core/author | "Taruselli M.A."xsd:string |
| http://purl.uniprot.org/citations/33723318 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33723318 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/33723318 | http://purl.uniprot.org/core/pages | "6044"xsd:string |
| http://purl.uniprot.org/citations/33723318 | http://purl.uniprot.org/core/title | "All-trans retinoic acid and protein kinase C alpha/beta1 inhibitor combined treatment targets cancer stem cells and impairs breast tumor progression."xsd:string |
| http://purl.uniprot.org/citations/33723318 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/33723318 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33723318 |
| http://purl.uniprot.org/citations/33723318 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33723318 |
| http://purl.uniprot.org/uniprot/#_Q4VA93-mappedCitation-33723318 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33723318 |