| http://purl.uniprot.org/citations/33730591 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33730591 | http://www.w3.org/2000/01/rdf-schema#comment | "T cells form immunological synapses with professional antigen-presenting cells (APCs) resulting in T cell activation and the acquisition of peptide antigen-MHC (pMHC) complexes from the plasma membrane of the APC. They thus become APCs themselves. We investigate the functional outcome of T-T cell antigen presentation by CD4 T cells and find that the antigen-presenting T cells (Tpres) predominantly differentiate into regulatory T cells (Treg), whereas T cells that have been stimulated by Tpres cells predominantly differentiate into Th17 pro-inflammatory cells. Using mice deficient in pMHC uptake by T cells, we show that T-T antigen presentation is important for the development of experimental autoimmune encephalitis and Th17 cell differentiation in vivo. By varying the professional APC:T cell ratio, we can modulate Treg versus Th17 differentiation in vitro and in vivo, suggesting that T-T antigen presentation underlies proinflammatory responses in conditions of antigen scarcity."xsd:string |
| http://purl.uniprot.org/citations/33730591 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2021.108861"xsd:string |
| http://purl.uniprot.org/citations/33730591 | http://purl.uniprot.org/core/author | "Alarcon B."xsd:string |
| http://purl.uniprot.org/citations/33730591 | http://purl.uniprot.org/core/author | "Prieto C."xsd:string |
| http://purl.uniprot.org/citations/33730591 | http://purl.uniprot.org/core/author | "Batista F.D."xsd:string |
| http://purl.uniprot.org/citations/33730591 | http://purl.uniprot.org/core/author | "Villanueva A."xsd:string |
| http://purl.uniprot.org/citations/33730591 | http://purl.uniprot.org/core/author | "Borroto A."xsd:string |
| http://purl.uniprot.org/citations/33730591 | http://purl.uniprot.org/core/author | "Diaz-Munoz M.D."xsd:string |
| http://purl.uniprot.org/citations/33730591 | http://purl.uniprot.org/core/author | "van Santen H.M."xsd:string |
| http://purl.uniprot.org/citations/33730591 | http://purl.uniprot.org/core/author | "Alonso-Lopez D."xsd:string |
| http://purl.uniprot.org/citations/33730591 | http://purl.uniprot.org/core/author | "Bovolenta E.R."xsd:string |
| http://purl.uniprot.org/citations/33730591 | http://purl.uniprot.org/core/author | "Oeste C.L."xsd:string |
| http://purl.uniprot.org/citations/33730591 | http://purl.uniprot.org/core/author | "Boccasavia V.L."xsd:string |
| http://purl.uniprot.org/citations/33730591 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33730591 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/33730591 | http://purl.uniprot.org/core/pages | "108861"xsd:string |
| http://purl.uniprot.org/citations/33730591 | http://purl.uniprot.org/core/title | "Antigen presentation between T cells drives Th17 polarization under conditions of limiting antigen."xsd:string |
| http://purl.uniprot.org/citations/33730591 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/33730591 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33730591 |
| http://purl.uniprot.org/citations/33730591 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33730591 |
| http://purl.uniprot.org/uniprot/#_A6H6M1-mappedCitation-33730591 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33730591 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GSL4-mappedCitation-33730591 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33730591 |
| http://purl.uniprot.org/uniprot/#_B2KKU6-mappedCitation-33730591 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33730591 |
| http://purl.uniprot.org/uniprot/#_B0LAX5-mappedCitation-33730591 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33730591 |