| http://purl.uniprot.org/citations/33732245 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33732245 | http://www.w3.org/2000/01/rdf-schema#comment | "Expression of tissue-restricted antigens (TRAs) in thymic epithelial cells (TECs) ensures negative selection of highly self-reactive T cells to establish central tolerance. Whether some of these TRAs could exert their canonical biological functions to shape thymic environment to regulate T cell development is unclear. Analyses of publicly available databases have revealed expression of transcripts at various levels of many cytokines and cytokine receptors such as IL-15, IL-15Rα, IL-13, and IL-23a in both human and mouse TECs. Ablation of either IL-15 or IL-15Rα in TECs selectively impairs type 1 innate like T cell, such as iNKT1 and γδT1 cell, development in the thymus, indicating that TECs not only serve as an important source of IL-15 but also trans-present IL-15 to ensure type 1 innate like T cell development. Because type 1 innate like T cells are proinflammatory, our data suggest the possibility that TEC may intrinsically control thymic inflammatory innate like T cells to influence thymic environment."xsd:string |
| http://purl.uniprot.org/citations/33732245 | http://purl.org/dc/terms/identifier | "doi:10.3389/fimmu.2021.623280"xsd:string |
| http://purl.uniprot.org/citations/33732245 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/33732245 | http://purl.uniprot.org/core/author | "Schluns K.S."xsd:string |
| http://purl.uniprot.org/citations/33732245 | http://purl.uniprot.org/core/author | "Tao H."xsd:string |
| http://purl.uniprot.org/citations/33732245 | http://purl.uniprot.org/core/author | "Luckhart S."xsd:string |
| http://purl.uniprot.org/citations/33732245 | http://purl.uniprot.org/core/author | "Zhong X.P."xsd:string |
| http://purl.uniprot.org/citations/33732245 | http://purl.uniprot.org/core/author | "Sleasman J.W."xsd:string |
| http://purl.uniprot.org/citations/33732245 | http://purl.uniprot.org/core/author | "Liao N.S."xsd:string |
| http://purl.uniprot.org/citations/33732245 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33732245 | http://purl.uniprot.org/core/name | "Front Immunol"xsd:string |
| http://purl.uniprot.org/citations/33732245 | http://purl.uniprot.org/core/pages | "623280"xsd:string |
| http://purl.uniprot.org/citations/33732245 | http://purl.uniprot.org/core/title | "Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor alpha Chain Foster Local Environment for Type 1 Innate Like T Cell Development."xsd:string |
| http://purl.uniprot.org/citations/33732245 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/33732245 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33732245 |
| http://purl.uniprot.org/citations/33732245 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33732245 |
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| http://purl.uniprot.org/uniprot/#_E9QA82-mappedCitation-33732245 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33732245 |
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| http://purl.uniprot.org/uniprot/#_K9N0C7-mappedCitation-33732245 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33732245 |
| http://purl.uniprot.org/uniprot/#_K9N163-mappedCitation-33732245 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33732245 |
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