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http://purl.uniprot.org/citations/33734613http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/33734613http://www.w3.org/2000/01/rdf-schema#comment"

Background

X-ray repair cross-complementary 5 (XRCC5) and 6 (XRCC6) are critical for DNA repair. Few studies have assessed their association with breast cancer risk, and related gene-environment interactions remain poorly understood. This study aimed to determine the influence of XRCC5/6 polymorphisms on breast cancer risk, and their interactions with cigarette smoking, alcohol consumption, and sleep satisfaction.

Methods

The study included 1039 patients with breast cancer and 1040 controls. Four single-nucleotide polymorphisms of XRCC5 and two of XRCC6 were genotyped. Information about smoking, alcohol consumption, and sleep satisfaction was collected through questionnaires. Odds ratios (OR) and related 95% confidence intervals (95% CI) were assessed using unconditional logistic regression models. Gene-environment interactions were analyzed using logistic regression with multiplicative interaction models.

Results

XRCC5 rs16855458 was associated with increased breast cancer risk in the co-dominant (ptrend  = 0.003) and dominant (CA + AA vs. CC, OR = 1.29, 95% CI = 1.07-1.56, p = 0.008) genetic models after Bonferroni correction. The CG + GG genotype of XRCC6 rs2267437 was associated with an increased risk of estrogen receptor-negative/progesterone receptor-negative (ER-/PR-) breast cancer (CG + GG vs. CC: OR = 1.54, 95% CI = 1.12-2.13, p = 0.008) after Bonferroni correction. Moreover, an antagonistic interaction between XRCC5 rs16855458 and alcohol consumption (pinteraction  = 0.017), and a synergistic interaction between XRCC6 rs2267437 and sleep satisfaction were associated with breast cancer risk (pinteraction  = 0.0497). However, these interactions became insignificant after Bonferroni correction.

Conclusion

XRCC5 rs16855458 was associated with breast cancer risk, and XRCC6 rs2267437 was associated with the risk of ER-/PR-breast cancer. Breast cancer risk associated with XRCC5 and XRCC6 polymorphisms might vary according to alcohol consumption and sleep satisfaction, respectively, and merit further investigation."xsd:string
http://purl.uniprot.org/citations/33734613http://purl.org/dc/terms/identifier"doi:10.1002/cam4.3847"xsd:string
http://purl.uniprot.org/citations/33734613http://purl.uniprot.org/core/author"Li L."xsd:string
http://purl.uniprot.org/citations/33734613http://purl.uniprot.org/core/author"Liang H."xsd:string
http://purl.uniprot.org/citations/33734613http://purl.uniprot.org/core/author"Wang S."xsd:string
http://purl.uniprot.org/citations/33734613http://purl.uniprot.org/core/author"Wang F."xsd:string
http://purl.uniprot.org/citations/33734613http://purl.uniprot.org/core/author"Wang X."xsd:string
http://purl.uniprot.org/citations/33734613http://purl.uniprot.org/core/author"Zheng C."xsd:string
http://purl.uniprot.org/citations/33734613http://purl.uniprot.org/core/author"Zhou F."xsd:string
http://purl.uniprot.org/citations/33734613http://purl.uniprot.org/core/author"Jin F."xsd:string
http://purl.uniprot.org/citations/33734613http://purl.uniprot.org/core/author"Yu L.X."xsd:string
http://purl.uniprot.org/citations/33734613http://purl.uniprot.org/core/author"Liu L.Y."xsd:string
http://purl.uniprot.org/citations/33734613http://purl.uniprot.org/core/author"Huang S.Y."xsd:string
http://purl.uniprot.org/citations/33734613http://purl.uniprot.org/core/author"Wang H.B."xsd:string
http://purl.uniprot.org/citations/33734613http://purl.uniprot.org/core/author"Yang Z.L."xsd:string
http://purl.uniprot.org/citations/33734613http://purl.uniprot.org/core/author"Zhang J.L."xsd:string
http://purl.uniprot.org/citations/33734613http://purl.uniprot.org/core/author"Jiang H.C."xsd:string
http://purl.uniprot.org/citations/33734613http://purl.uniprot.org/core/author"Ye C.M."xsd:string
http://purl.uniprot.org/citations/33734613http://purl.uniprot.org/core/author"Li G.L."xsd:string
http://purl.uniprot.org/citations/33734613http://purl.uniprot.org/core/author"Zhang J.G."xsd:string
http://purl.uniprot.org/citations/33734613http://purl.uniprot.org/core/author"Yu Z.G."xsd:string
http://purl.uniprot.org/citations/33734613http://purl.uniprot.org/core/author"Tang J.H."xsd:string
http://purl.uniprot.org/citations/33734613http://purl.uniprot.org/core/author"Zhou W.Z."xsd:string
http://purl.uniprot.org/citations/33734613http://purl.uniprot.org/core/author"Ma Z.B."xsd:string
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