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http://purl.uniprot.org/citations/33734973http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/33734973http://www.w3.org/2000/01/rdf-schema#comment"

Objectives

To determine if patients with the predominant extracranial large-vessel-vasculitis (LVV) pattern of giant cell arteritis (GCA) have a distinctive HLA-B association, different from that reported in biopsy-proven cranial GCA patients. In a further step we assessed if the combination of HLA-B and HLA-DRB1 alleles confers an increased risk for GCA susceptibility, either for the cranial and extracranial LVV phenotypes.

Methods

A total of 184 patients with biopsy-proven cranial GCA, 105 with LVV-GCA and 486 healthy controls were included in our study. We compared HLA-B phenotype frequencies between the three groups.

Results

HLA-B*15 phenotype was significantly increased in patients with classic cranial GCA compared to controls (14.7% versus 5.8%, respectively; p<0.01; OR [95% CI] =2.81 [1.54-5.11]). It was mainly due to the HLA-B*15:01 allele (12.5% versus 4.0%, respectively; p<0.01; OR [95% CI] =3.51 [1.77-6.99]) and remained statistically significant after Bonferroni correction. Similar HLA-B*15 association was observed in patients with the LVV-GCA (11.4% versus 5.8%, p=0.04, OR [95% CI] =2.11 [1.04-4.30]). This association was also mainly due to the HLA-B*15:01 allele (10.5% versus 4.0%, respectively; p=0.0054; OR [95% CI] =2.88 [1.19-6.59]). Noteworthy, the presence of HLA-B*15:01 together with HLA-DRB1*04:01 led to an increased risk of developing both cranial and extracranial LVV-GCA.

Conclusions

Susceptibility to GCA is strongly related to the HLA region, regardless of the clinical phenotype of expression of the disease."xsd:string
http://purl.uniprot.org/citations/33734973http://purl.org/dc/terms/identifier"doi:10.55563/clinexprheumatol/nn15lt"xsd:string
http://purl.uniprot.org/citations/33734973http://purl.uniprot.org/core/author"Martin J."xsd:string
http://purl.uniprot.org/citations/33734973http://purl.uniprot.org/core/author"Blanco R."xsd:string
http://purl.uniprot.org/citations/33734973http://purl.uniprot.org/core/author"Gonzalez-Gay M.A."xsd:string
http://purl.uniprot.org/citations/33734973http://purl.uniprot.org/core/author"Ocejo-Vinyals J.G."xsd:string
http://purl.uniprot.org/citations/33734973http://purl.uniprot.org/core/author"Garcia-Garcia J."xsd:string
http://purl.uniprot.org/citations/33734973http://purl.uniprot.org/core/author"Gualillo O."xsd:string
http://purl.uniprot.org/citations/33734973http://purl.uniprot.org/core/author"Ortego-Centeno N."xsd:string
http://purl.uniprot.org/citations/33734973http://purl.uniprot.org/core/author"Castaneda S."xsd:string
http://purl.uniprot.org/citations/33734973http://purl.uniprot.org/core/author"Llorente I."xsd:string
http://purl.uniprot.org/citations/33734973http://purl.uniprot.org/core/author"Remuzgo-Martinez S."xsd:string
http://purl.uniprot.org/citations/33734973http://purl.uniprot.org/core/author"Calvo I."xsd:string
http://purl.uniprot.org/citations/33734973http://purl.uniprot.org/core/author"Miranda-Filloy J.A."xsd:string
http://purl.uniprot.org/citations/33734973http://purl.uniprot.org/core/author"Lopez-Mejias R."xsd:string
http://purl.uniprot.org/citations/33734973http://purl.uniprot.org/core/author"Genre F."xsd:string
http://purl.uniprot.org/citations/33734973http://purl.uniprot.org/core/author"Romero-Yuste S."xsd:string
http://purl.uniprot.org/citations/33734973http://purl.uniprot.org/core/author"Galindez-Agirregoikoa E."xsd:string
http://purl.uniprot.org/citations/33734973http://purl.uniprot.org/core/author"Atienza-Mateo B."xsd:string
http://purl.uniprot.org/citations/33734973http://purl.uniprot.org/core/author"Prieto-Pena D."xsd:string
http://purl.uniprot.org/citations/33734973http://purl.uniprot.org/core/author"Moriano C."xsd:string
http://purl.uniprot.org/citations/33734973http://purl.uniprot.org/core/author"Munoz-Jimenez A."xsd:string
http://purl.uniprot.org/citations/33734973http://purl.uniprot.org/core/author"Ortiz-Sanjuan F."xsd:string
http://purl.uniprot.org/citations/33734973http://purl.uniprot.org/core/author"Alvarez-Rivas N."xsd:string
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