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| http://purl.uniprot.org/citations/33741415 | http://www.w3.org/2000/01/rdf-schema#comment | "β-arrestin2 is a ubiquitously expressed scaffold protein localized on the cytoplasm and plasma membrane. It was originally found to bind to GPCRs, uncoupling G proteins and receptors' binding and inhibiting the signal transduction of the GPCRs. Further investigations have revealed that β-arrestin2 not only mediates the desensitization of GPCRs but also serves as a multifunctional scaffold to mediate receptor internalization, kinase activation, and regulation of various signaling pathways, such as TLR4/NF-κB, MAPK, Wnt, TGF-β, and AMPK/mTOR pathways. β-arrestin2 regulates cell invasion, migration, autophagy, angiogenesis, and anti-inflammatory effects by regulating various signaling pathways, which play a vital role in many physiological and pathological processes. This paper reviews the structure and function of β-arrestin2, the regulation of β-arrestin2 based signaling pathways. The role and mechanism of β-arrestin2 signaling have been delineated in sufficient detail. The prospect of regulating the expression and activity of β-arrestin2 in multisystem diseases holds substantial therapeutic promise."xsd:string |
| http://purl.uniprot.org/citations/33741415 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.lfs.2021.119364"xsd:string |
| http://purl.uniprot.org/citations/33741415 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/33741415 | http://purl.uniprot.org/core/author | "Zhang C.Y."xsd:string |
| http://purl.uniprot.org/citations/33741415 | http://purl.uniprot.org/core/author | "Duan J.X."xsd:string |
| http://purl.uniprot.org/citations/33741415 | http://purl.uniprot.org/core/author | "Ma T.L."xsd:string |
| http://purl.uniprot.org/citations/33741415 | http://purl.uniprot.org/core/author | "Gao Z.A."xsd:string |
| http://purl.uniprot.org/citations/33741415 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33741415 | http://purl.uniprot.org/core/name | "Life Sci"xsd:string |
| http://purl.uniprot.org/citations/33741415 | http://purl.uniprot.org/core/pages | "119364"xsd:string |
| http://purl.uniprot.org/citations/33741415 | http://purl.uniprot.org/core/title | "The role and mechanism of beta-arrestin2 in signal transduction."xsd:string |
| http://purl.uniprot.org/citations/33741415 | http://purl.uniprot.org/core/volume | "275"xsd:string |
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