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Background

Gliomas, particularly high-grade gliomas, are the most common primary brain tumors. From the Chinese Glioma Genome Atlas (CGGA) database, the relationships between the altered molecular pathways and gliomas could be easily observed. A close connection in the occurrence of the pathogenesis exists between the microenvironment, the glioma, and the associated genes.

Methods

Validation of the role of ZNF311 oncogene was confirmed by data from the CGGA dataset on glioblastoma and low-grade glioma. Furthermore, we used CIBERSORT to analyze the correlation between ZNF311 and cancer immune infiltrates.

Results

According to our analysis, ZNF311 was expressed higher in patients with grade-depended glioma with poor prognosis. In addition, we obtained valuable prognostic results between isocitrate dehydrogenase 1 (IDH1) and ZNF311 through the analysis of integrated correlations. Similarly, we simultaneously revealed the prognostic results between 1p/19q and ZNF311. In addition, we found that ZNF311 is correlated with a large number of tumor-infiltrating immune cells.

Conclusions

Based on the study findings, we conclude that ZNF311 is potentially a novel biomarker for assessing prognosis and immune infiltration in glioblastoma and diffuse glioma cases."xsd:string
http://purl.uniprot.org/citations/33746099http://purl.org/dc/terms/identifier"doi:10.1016/j.wneu.2021.03.064"xsd:string
http://purl.uniprot.org/citations/33746099http://purl.uniprot.org/core/author"Cai Z."xsd:string
http://purl.uniprot.org/citations/33746099http://purl.uniprot.org/core/author"Ge X."xsd:string
http://purl.uniprot.org/citations/33746099http://purl.uniprot.org/core/author"Jiang S."xsd:string
http://purl.uniprot.org/citations/33746099http://purl.uniprot.org/core/author"Zhang Y."xsd:string
http://purl.uniprot.org/citations/33746099http://purl.uniprot.org/core/author"Wang Z."xsd:string
http://purl.uniprot.org/citations/33746099http://purl.uniprot.org/core/author"Wu B."xsd:string
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http://purl.uniprot.org/citations/33746099http://purl.uniprot.org/core/author"Jiang R."xsd:string
http://purl.uniprot.org/citations/33746099http://purl.uniprot.org/core/author"Hu N."xsd:string
http://purl.uniprot.org/citations/33746099http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/33746099http://purl.uniprot.org/core/name"World Neurosurg"xsd:string
http://purl.uniprot.org/citations/33746099http://purl.uniprot.org/core/pages"e37-e46"xsd:string
http://purl.uniprot.org/citations/33746099http://purl.uniprot.org/core/title"Prognostic Biomarker ZNF311 and Its Correlation With Tumor Progression and Immune Infiltrates in Glioma."xsd:string
http://purl.uniprot.org/citations/33746099http://purl.uniprot.org/core/volume"151"xsd:string
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