| http://purl.uniprot.org/citations/33758062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33758062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33758062 | http://www.w3.org/2000/01/rdf-schema#comment | "NAADP-evoked Ca2+ release through type 1 ryanodine receptors (RYR1) is a major mechanism underlying the earliest signals in T cell activation, which are the formation of Ca2+ microdomains. In our characterization of the molecular machinery underlying NAADP action, we identified an NAADP-binding protein, called hematological and neurological expressed 1-like protein (HN1L) [also known as Jupiter microtubule-associated homolog 2 (JPT2)]. Gene deletion of Hn1l/Jpt2 in human Jurkat and primary rat T cells resulted in decreased numbers of initial Ca2+ microdomains and delayed the onset and decreased the amplitude of global Ca2+ signaling. Photoaffinity labeling demonstrated direct binding of NAADP to recombinant HN1L/JPT2. T cell receptor/CD3-dependent coprecipitation of HN1L/JPT2 with RYRs and colocalization of these proteins suggest that HN1L/JPT2 connects NAADP formation with the activation of RYR channels within the first seconds of T cell activation. Thus, HN1L/JPT2 enables NAADP to activate Ca2+ release from the endoplasmic reticulum through RYR."xsd:string |
| http://purl.uniprot.org/citations/33758062 | http://purl.org/dc/terms/identifier | "doi:10.1126/scisignal.abd5647"xsd:string |
| http://purl.uniprot.org/citations/33758062 | http://purl.org/dc/terms/identifier | "doi:10.1126/scisignal.abd5647"xsd:string |
| http://purl.uniprot.org/citations/33758062 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/33758062 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/33758062 | http://purl.uniprot.org/core/author | "Meier C."xsd:string |
| http://purl.uniprot.org/citations/33758062 | http://purl.uniprot.org/core/author | "Meier C."xsd:string |
| http://purl.uniprot.org/citations/33758062 | http://purl.uniprot.org/core/author | "Krueger A."xsd:string |
| http://purl.uniprot.org/citations/33758062 | http://purl.uniprot.org/core/author | "Krueger A."xsd:string |
| http://purl.uniprot.org/citations/33758062 | http://purl.uniprot.org/core/author | "Gu F."xsd:string |
| http://purl.uniprot.org/citations/33758062 | http://purl.uniprot.org/core/author | "Gu F."xsd:string |
| http://purl.uniprot.org/citations/33758062 | http://purl.uniprot.org/core/author | "Werner R."xsd:string |
| http://purl.uniprot.org/citations/33758062 | http://purl.uniprot.org/core/author | "Werner R."xsd:string |
| http://purl.uniprot.org/citations/33758062 | http://purl.uniprot.org/core/author | "Schlueter H."xsd:string |
| http://purl.uniprot.org/citations/33758062 | http://purl.uniprot.org/core/author | "Schlueter H."xsd:string |
| http://purl.uniprot.org/citations/33758062 | http://purl.uniprot.org/core/author | "Bauche A."xsd:string |
| http://purl.uniprot.org/citations/33758062 | http://purl.uniprot.org/core/author | "Bauche A."xsd:string |
| http://purl.uniprot.org/citations/33758062 | http://purl.uniprot.org/core/author | "Walseth T.F."xsd:string |
| http://purl.uniprot.org/citations/33758062 | http://purl.uniprot.org/core/author | "Walseth T.F."xsd:string |
| http://purl.uniprot.org/citations/33758062 | http://purl.uniprot.org/core/author | "Diercks B.P."xsd:string |
| http://purl.uniprot.org/citations/33758062 | http://purl.uniprot.org/core/author | "Diercks B.P."xsd:string |
| http://purl.uniprot.org/citations/33758062 | http://purl.uniprot.org/core/author | "Failla A.V."xsd:string |
| http://purl.uniprot.org/citations/33758062 | http://purl.uniprot.org/core/author | "Failla A.V."xsd:string |