| http://purl.uniprot.org/citations/33758932 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33758932 | http://www.w3.org/2000/01/rdf-schema#comment | "We examined the effect of microRNA-320b (miR-320b) on tumor growth and angiogenesis in lung cancer and also determined its downstream molecular mechanisms. Lung cancer tissues and adjacent non-cancerous tissues were collected from 66 patients with lung cancer. miR-320b expression was experimentally determined to be expressed at low level in cancer tissues. The results of gain-of-function experiments suggested that miR-320b overexpression suppressed cancer cell invasion, tube formation, tumor volume and angiogenesis in xenografted nude mice. Hepatocyte nuclear factor 4 gamma (HNF4G) was identified as a target of miR-320b based on in silico analysis. Dual-luciferase reporter gene assays further identified the binding relationship between HNF4G and miR-320b. Lung cancer tissues exhibited increased expression of HNF4G and insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2). Meanwhile, HNF4G knockdown suppressed IGF2BP2 expression, thereby repressing cancer cell invasion and tube formation. Furthermore, IGF2BP2 modified m6A to increase the expression of thymidine kinase 1 (TK1), thus promoting angiogenesis. In nude mice, restoration of TK1 reversed the suppressive effect of miR-320b overexpression on tumor growth rate and CD31 expression. In conclusion, miR-320b suppresses lung cancer growth and angiogenesis by inhibiting HNF4G, IGF2BP2 and TK1."xsd:string |
| http://purl.uniprot.org/citations/33758932 | http://purl.org/dc/terms/identifier | "doi:10.1093/carcin/bgab023"xsd:string |
| http://purl.uniprot.org/citations/33758932 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/33758932 | http://purl.uniprot.org/core/author | "Yu F."xsd:string |
| http://purl.uniprot.org/citations/33758932 | http://purl.uniprot.org/core/author | "Wu W."xsd:string |
| http://purl.uniprot.org/citations/33758932 | http://purl.uniprot.org/core/author | "Wang P.Y."xsd:string |
| http://purl.uniprot.org/citations/33758932 | http://purl.uniprot.org/core/author | "Zhang J.J."xsd:string |
| http://purl.uniprot.org/citations/33758932 | http://purl.uniprot.org/core/author | "Yang X.L."xsd:string |
| http://purl.uniprot.org/citations/33758932 | http://purl.uniprot.org/core/author | "Wang G.R."xsd:string |
| http://purl.uniprot.org/citations/33758932 | http://purl.uniprot.org/core/author | "Wu C.Y."xsd:string |
| http://purl.uniprot.org/citations/33758932 | http://purl.uniprot.org/core/author | "Fu D."xsd:string |
| http://purl.uniprot.org/citations/33758932 | http://purl.uniprot.org/core/author | "Guo J.H."xsd:string |
| http://purl.uniprot.org/citations/33758932 | http://purl.uniprot.org/core/author | "Yang H.Q."xsd:string |
| http://purl.uniprot.org/citations/33758932 | http://purl.uniprot.org/core/author | "Zhang D.D."xsd:string |
| http://purl.uniprot.org/citations/33758932 | http://purl.uniprot.org/core/author | "Wang H.M."xsd:string |
| http://purl.uniprot.org/citations/33758932 | http://purl.uniprot.org/core/author | "Jia C.Y."xsd:string |
| http://purl.uniprot.org/citations/33758932 | http://purl.uniprot.org/core/author | "Lu G.X."xsd:string |
| http://purl.uniprot.org/citations/33758932 | http://purl.uniprot.org/core/author | "Ma Y.S."xsd:string |
| http://purl.uniprot.org/citations/33758932 | http://purl.uniprot.org/core/author | "Xin R."xsd:string |
| http://purl.uniprot.org/citations/33758932 | http://purl.uniprot.org/core/author | "Liu J.B."xsd:string |
| http://purl.uniprot.org/citations/33758932 | http://purl.uniprot.org/core/author | "Tian L.L."xsd:string |
| http://purl.uniprot.org/citations/33758932 | http://purl.uniprot.org/core/author | "Yin Y.Z."xsd:string |
| http://purl.uniprot.org/citations/33758932 | http://purl.uniprot.org/core/author | "Jiang G.X."xsd:string |
| http://purl.uniprot.org/citations/33758932 | http://purl.uniprot.org/core/author | "Shi B.W."xsd:string |