| http://purl.uniprot.org/citations/33763060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33763060 | http://www.w3.org/2000/01/rdf-schema#comment | "Heritability of Spondyloarthritis (SpA) is highlighted by several familial studies and a high association with the presence of human leukocyte antigen (HLA)-B*27. Though it has been over four decades since the association of HLA-B*27 with SpA was first determined, the pathophysiological roles played by specific HLA-B*27 allotypes are not fully understood. Popular hypotheses include the presentation of arthritogenic peptides, triggering of endoplasmic reticulum (ER) stress by misfolded HLA-B*27, and the interaction between free heavy chains or heavy chain homodimers of HLA-B*27 and immune receptors to drive IL-17 responses. Several non-HLA susceptibility loci have also been identified for SpA, including endoplasmic reticulum aminopeptidases (ERAP) and those related to the IL-23/IL-17 axes. In this review, we summarize clinical aspects of SpA including known characteristics of gut inflammation, enthesitis and new bone formation and the existing models for understanding the association of HLA-B*27 with disease pathogenesis. We also examine newer insights into the biology of HLA class I (HLA-I) proteins and their implications for expanding our understanding of HLA-B*27 contributions to SpA pathogenesis."xsd:string |
| http://purl.uniprot.org/citations/33763060 | http://purl.org/dc/terms/identifier | "doi:10.3389/fimmu.2021.601518"xsd:string |
| http://purl.uniprot.org/citations/33763060 | http://purl.uniprot.org/core/author | "Geng J."xsd:string |
| http://purl.uniprot.org/citations/33763060 | http://purl.uniprot.org/core/author | "Raghavan M."xsd:string |
| http://purl.uniprot.org/citations/33763060 | http://purl.uniprot.org/core/author | "Negi V.S."xsd:string |
| http://purl.uniprot.org/citations/33763060 | http://purl.uniprot.org/core/author | "Bulusu S.N."xsd:string |
| http://purl.uniprot.org/citations/33763060 | http://purl.uniprot.org/core/author | "Kavadichanda C.G."xsd:string |
| http://purl.uniprot.org/citations/33763060 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33763060 | http://purl.uniprot.org/core/name | "Front Immunol"xsd:string |
| http://purl.uniprot.org/citations/33763060 | http://purl.uniprot.org/core/pages | "601518"xsd:string |
| http://purl.uniprot.org/citations/33763060 | http://purl.uniprot.org/core/title | "Spondyloarthritis and the Human Leukocyte Antigen (HLA)-B*27 Connection."xsd:string |
| http://purl.uniprot.org/citations/33763060 | http://purl.uniprot.org/core/volume | "12"xsd:string |
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| http://purl.uniprot.org/citations/33763060 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33763060 |
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