| http://purl.uniprot.org/citations/33767202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33767202 | http://www.w3.org/2000/01/rdf-schema#comment | "B cells have essential functions in multiple sclerosis and in its mouse model, experimental autoimmune encephalomyelitis, both as drivers and suppressors of the disease. The suppressive effects are driven by a regulatory B cell (Breg) population that functions, primarily but not exclusively, via the production of IL-10. However, the mechanisms modulating IL-10-producing Breg abundance are poorly understood. Here we identify SLAMF5 for controlling IL-10+ Breg maintenance and function. In EAE, the deficiency of SLAMF5 in B cells causes accumulation of IL10+ Bregs in the central nervous system and periphery. Blocking SLAMF5 in vitro induces both human and mouse IL-10-producing Breg cells and increases their survival with a concomitant increase of a transcription factor, c-Maf. Finally, in vivo SLAMF5 blocking in EAE elevates IL-10+ Breg levels and ameliorates disease severity. Our results suggest that SLAMF5 is a negative moderator of IL-10+ Breg cells, and may serve as a therapeutic target in MS and other autoimmune diseases."xsd:string |
| http://purl.uniprot.org/citations/33767202 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-021-22230-z"xsd:string |
| http://purl.uniprot.org/citations/33767202 | http://purl.uniprot.org/core/author | "David K."xsd:string |
| http://purl.uniprot.org/citations/33767202 | http://purl.uniprot.org/core/author | "Shachar I."xsd:string |
| http://purl.uniprot.org/citations/33767202 | http://purl.uniprot.org/core/author | "Becker-Herman S."xsd:string |
| http://purl.uniprot.org/citations/33767202 | http://purl.uniprot.org/core/author | "Kramer M.P."xsd:string |
| http://purl.uniprot.org/citations/33767202 | http://purl.uniprot.org/core/author | "Radomir L."xsd:string |
| http://purl.uniprot.org/citations/33767202 | http://purl.uniprot.org/core/author | "Aharoni R."xsd:string |
| http://purl.uniprot.org/citations/33767202 | http://purl.uniprot.org/core/author | "Milo R."xsd:string |
| http://purl.uniprot.org/citations/33767202 | http://purl.uniprot.org/core/author | "Mauri C."xsd:string |
| http://purl.uniprot.org/citations/33767202 | http://purl.uniprot.org/core/author | "Wiener A."xsd:string |
| http://purl.uniprot.org/citations/33767202 | http://purl.uniprot.org/core/author | "Lewinsky H."xsd:string |
| http://purl.uniprot.org/citations/33767202 | http://purl.uniprot.org/core/author | "Schottlender N."xsd:string |
| http://purl.uniprot.org/citations/33767202 | http://purl.uniprot.org/core/author | "Rabani S."xsd:string |
| http://purl.uniprot.org/citations/33767202 | http://purl.uniprot.org/core/author | "Perpinial M."xsd:string |
| http://purl.uniprot.org/citations/33767202 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33767202 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/33767202 | http://purl.uniprot.org/core/pages | "1893"xsd:string |
| http://purl.uniprot.org/citations/33767202 | http://purl.uniprot.org/core/title | "The survival and function of IL-10-producing regulatory B cells are negatively controlled by SLAMF5."xsd:string |
| http://purl.uniprot.org/citations/33767202 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/33767202 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33767202 |
| http://purl.uniprot.org/citations/33767202 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33767202 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0K5-mappedCitation-33767202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33767202 |
| http://purl.uniprot.org/uniprot/#_E9Q9E8-mappedCitation-33767202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33767202 |