| http://purl.uniprot.org/citations/33772115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33772115 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumour evolution is driven by both genetic and epigenetic changes. CENP-A, the centromeric histone H3 variant, is an epigenetic mark that directly perturbs genetic stability and chromatin when overexpressed. Although CENP-A overexpression is a common feature of many cancers, how this impacts cell fate and response to therapy remains unclear. Here, we established a tunable system of inducible and reversible CENP-A overexpression combined with a switch in p53 status in human cell lines. Through clonogenic survival assays, single-cell RNA-sequencing and cell trajectory analysis, we uncover the tumour suppressor p53 as a key determinant of how CENP-A impacts cell state, cell identity and therapeutic response. If p53 is functional, CENP-A overexpression promotes senescence and radiosensitivity. Surprisingly, when we inactivate p53, CENP-A overexpression instead promotes epithelial-mesenchymal transition, an essential process in mammalian development but also a precursor for tumour cell invasion and metastasis. Thus, we uncover an unanticipated function of CENP-A overexpression to promote cell fate reprogramming, with important implications for development and tumour evolution."xsd:string |
| http://purl.uniprot.org/citations/33772115 | http://purl.org/dc/terms/identifier | "doi:10.1038/s42003-021-01941-5"xsd:string |
| http://purl.uniprot.org/citations/33772115 | http://purl.uniprot.org/core/author | "Dumont M."xsd:string |
| http://purl.uniprot.org/citations/33772115 | http://purl.uniprot.org/core/author | "Almouzni G."xsd:string |
| http://purl.uniprot.org/citations/33772115 | http://purl.uniprot.org/core/author | "Fachinetti D."xsd:string |
| http://purl.uniprot.org/citations/33772115 | http://purl.uniprot.org/core/author | "Jeffery D."xsd:string |
| http://purl.uniprot.org/citations/33772115 | http://purl.uniprot.org/core/author | "Podsypanina K."xsd:string |
| http://purl.uniprot.org/citations/33772115 | http://purl.uniprot.org/core/author | "Gatto A."xsd:string |
| http://purl.uniprot.org/citations/33772115 | http://purl.uniprot.org/core/author | "Bonneville L."xsd:string |
| http://purl.uniprot.org/citations/33772115 | http://purl.uniprot.org/core/author | "Ponce Landete R."xsd:string |
| http://purl.uniprot.org/citations/33772115 | http://purl.uniprot.org/core/author | "Renaud-Pageot C."xsd:string |
| http://purl.uniprot.org/citations/33772115 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33772115 | http://purl.uniprot.org/core/name | "Commun Biol"xsd:string |
| http://purl.uniprot.org/citations/33772115 | http://purl.uniprot.org/core/pages | "417"xsd:string |
| http://purl.uniprot.org/citations/33772115 | http://purl.uniprot.org/core/title | "CENP-A overexpression promotes distinct fates in human cells, depending on p53 status."xsd:string |
| http://purl.uniprot.org/citations/33772115 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/33772115 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33772115 |
| http://purl.uniprot.org/citations/33772115 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33772115 |
| http://purl.uniprot.org/uniprot/#_A0A0A0U7X4-mappedCitation-33772115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33772115 |
| http://purl.uniprot.org/uniprot/#_A0A0M4B4Y9-mappedCitation-33772115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33772115 |
| http://purl.uniprot.org/uniprot/#_A0A087WXZ1-mappedCitation-33772115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33772115 |
| http://purl.uniprot.org/uniprot/#_A0A0C4KX50-mappedCitation-33772115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33772115 |
| http://purl.uniprot.org/uniprot/#_A0A0C4L134-mappedCitation-33772115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33772115 |
| http://purl.uniprot.org/uniprot/#_A0A087X1Q1-mappedCitation-33772115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33772115 |