| http://purl.uniprot.org/citations/33786818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33786818 | http://www.w3.org/2000/01/rdf-schema#comment | "The dorsal cochlear nucleus (DCN) is a mammalian-specific nucleus of the auditory system. Anatomically, it is classified as a cerebellum-like structure. These structures are proposed to share genetic programs with the cerebellum. Previous analyses demonstrated that inhibitory serial sister cell types (SCTs) of the DCN and cerebellum are derived from the pancreatic transcription factor 1a (Ptf1a) lineage. Postmitotic neurons of the Ptf1a lineage often express the transcription factor Ladybird homeobox protein homolog 1 (Lbx1) which is involved in neuronal cell fate determination. Lbx1 is therefore an attractive candidate for a further component of the genetic program shared between the DCN and cerebellum. Here, we used cell-type specific marker analysis in combination with an Lbx1 reporter mouse line to analyze in both tissues which cell types of the Ptf1a lineage express Lbx1. In the DCN, stellate cells and Purkinje-like cartwheel cells were part of the Lbx1 lineage and Golgi cells were not, as determined by cell counts. In contrast, in the cerebellum, stellate cells and Golgi cells were part of the Lbx1 lineage and Purkinje cells were not. Hence, two out of three phenotypically similar cell types differed with respect to their Lbx1 expression. Our study demonstrates that Lbx1 is differentially recruited to the developmental genetic program of inhibitory neurons both within a given tissue and between the DCN and cerebellum. The differential expression of Lbx1 within the DCN and the cerebellum might contribute to the genetic individuation of the inhibitory SCTs to adapt to circuit specific tasks."xsd:string |
| http://purl.uniprot.org/citations/33786818 | http://purl.org/dc/terms/identifier | "doi:10.1002/cne.25147"xsd:string |
| http://purl.uniprot.org/citations/33786818 | http://purl.uniprot.org/core/author | "Nothwang H.G."xsd:string |
| http://purl.uniprot.org/citations/33786818 | http://purl.uniprot.org/core/author | "Ebbers L."xsd:string |
| http://purl.uniprot.org/citations/33786818 | http://purl.uniprot.org/core/author | "Schinzel F."xsd:string |
| http://purl.uniprot.org/citations/33786818 | http://purl.uniprot.org/core/author | "Seyfer H."xsd:string |
| http://purl.uniprot.org/citations/33786818 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33786818 | http://purl.uniprot.org/core/name | "J Comp Neurol"xsd:string |
| http://purl.uniprot.org/citations/33786818 | http://purl.uniprot.org/core/pages | "3032-3045"xsd:string |
| http://purl.uniprot.org/citations/33786818 | http://purl.uniprot.org/core/title | "The Lbx1 lineage differentially contributes to inhibitory cell types of the dorsal cochlear nucleus, a cerebellum-like structure, and the cerebellum."xsd:string |
| http://purl.uniprot.org/citations/33786818 | http://purl.uniprot.org/core/volume | "529"xsd:string |
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| http://purl.uniprot.org/uniprot/#_P63015-mappedCitation-33786818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33786818 |
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| http://purl.uniprot.org/uniprot/#_A2A412-mappedCitation-33786818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33786818 |