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http://purl.uniprot.org/citations/33788000http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/33788000http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To detect premature gluco-metabolic defects among night shift workers with disturbances in circadian rhythms.

Design and methods

We performed a hypothesis-generating, cross-sectional analysis of anthropometric, metabolic, lipid, and inflammation parameters, comparing active (a-NSW, n = 111) and former (f-NSW, n = 98) rotating night shift workers with diurnal workers (controls, n = 69). All participants were hospital nurses. We also evaluated the Pittsburgh Sleep Quality Index (PSQI) and assessed expression of transcription factors REV-ERBα and BMAL1 in peripheral blood mononuclear cells (PBMCs), as indicators of the molecular clock.

Results

Both a-NSW and f-NSW participants had significantly higher glycated hemoglobin (HbA1c) and white blood cell counts (WBC) (p < 0.001 for both), PSQI global score (p = 0.001) and diastolic blood pressure levels (p = 0.024) compared with controls. Expression of REV-ERBα/BMAL1 RNA in PBMC was significantly higher in a-NSW (p = 0.05) than in f-NSW or control participants. Multivariate regression analysis showed that working status and PSQI were independent determinants of higher HbA1c levels (p < 0.001).

Conclusions

We demonstrated that young, healthy night shift workers show subclinical abnormalities in HbA1c and changes in peripheral clock gene expression."xsd:string
http://purl.uniprot.org/citations/33788000http://purl.org/dc/terms/identifier"doi:10.1007/s00592-021-01676-z"xsd:string
http://purl.uniprot.org/citations/33788000http://purl.uniprot.org/core/author"Rizza S."xsd:string
http://purl.uniprot.org/citations/33788000http://purl.uniprot.org/core/author"Grant P.J."xsd:string
http://purl.uniprot.org/citations/33788000http://purl.uniprot.org/core/author"Staels B."xsd:string
http://purl.uniprot.org/citations/33788000http://purl.uniprot.org/core/author"Magrini A."xsd:string
http://purl.uniprot.org/citations/33788000http://purl.uniprot.org/core/author"Federici M."xsd:string
http://purl.uniprot.org/citations/33788000http://purl.uniprot.org/core/author"Porzio O."xsd:string
http://purl.uniprot.org/citations/33788000http://purl.uniprot.org/core/author"Menghini R."xsd:string
http://purl.uniprot.org/citations/33788000http://purl.uniprot.org/core/author"Hannemann J."xsd:string
http://purl.uniprot.org/citations/33788000http://purl.uniprot.org/core/author"Marx N."xsd:string
http://purl.uniprot.org/citations/33788000http://purl.uniprot.org/core/author"Luzi A."xsd:string
http://purl.uniprot.org/citations/33788000http://purl.uniprot.org/core/author"Massimi A."xsd:string
http://purl.uniprot.org/citations/33788000http://purl.uniprot.org/core/author"Boger R.H."xsd:string
http://purl.uniprot.org/citations/33788000http://purl.uniprot.org/core/author"Lehrke M."xsd:string
http://purl.uniprot.org/citations/33788000http://purl.uniprot.org/core/author"Mavilio M."xsd:string
http://purl.uniprot.org/citations/33788000http://purl.uniprot.org/core/author"Ballanti M."xsd:string
http://purl.uniprot.org/citations/33788000http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/33788000http://purl.uniprot.org/core/name"Acta Diabetol"xsd:string
http://purl.uniprot.org/citations/33788000http://purl.uniprot.org/core/pages"1111-1117"xsd:string
http://purl.uniprot.org/citations/33788000http://purl.uniprot.org/core/title"Alterations in Rev-ERBalpha/BMAL1 ratio and glycated hemoglobin in rotating shift workers: the EuRhythDia study."xsd:string
http://purl.uniprot.org/citations/33788000http://purl.uniprot.org/core/volume"58"xsd:string
http://purl.uniprot.org/citations/33788000http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/33788000
http://purl.uniprot.org/citations/33788000http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/33788000
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