| http://purl.uniprot.org/citations/33789099 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33789099 | http://www.w3.org/2000/01/rdf-schema#comment | "Neutrophils with immunoregulatory properties, also referred to as type-2 neutrophils (N2), myeloid-derived suppressor cells (MDSCs), or tumor-associated neutrophils (TANs), comprise a heterogeneous subset of cells that arise from unknown precursors in response to poorly understood cues. Here, we find that, in several models of liver autoimmunity, pharmacologically induced, autoantigen-specific T regulatory type-1 (TR1) cells and TR1-cell-induced B regulatory (Breg) cells use five immunoregulatory cytokines to coordinately recruit neutrophils into the liver and program their transcriptome to generate regulatory neutrophils. The liver-associated neutrophils from the treated mice, unlike their circulating counterparts or the liver neutrophils of sick mice lacking antigen-specific TR1 cells, are proliferative, can transfer disease protection to immunocompromised hosts engrafted with pathogenic effectors, and blunt antigen-presentation and local autoimmune responses via cathelin-related anti-microbial peptide (CRAMP), a cathelicidin, in a CRAMP-receptor-dependent manner. These results, thus, identify antigen-specific regulatory T cells as drivers of tissue-restricted regulatory neutrophil formation and CRAMP as an effector of regulatory neutrophil-mediated immunoregulation."xsd:string |
| http://purl.uniprot.org/citations/33789099 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2021.108919"xsd:string |
| http://purl.uniprot.org/citations/33789099 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/33789099 | http://purl.uniprot.org/core/author | "Mohapatra S."xsd:string |
| http://purl.uniprot.org/citations/33789099 | http://purl.uniprot.org/core/author | "Santamaria P."xsd:string |
| http://purl.uniprot.org/citations/33789099 | http://purl.uniprot.org/core/author | "Vignali D.A.A."xsd:string |
| http://purl.uniprot.org/citations/33789099 | http://purl.uniprot.org/core/author | "Ortega M."xsd:string |
| http://purl.uniprot.org/citations/33789099 | http://purl.uniprot.org/core/author | "Clarke R."xsd:string |
| http://purl.uniprot.org/citations/33789099 | http://purl.uniprot.org/core/author | "Kubes P."xsd:string |
| http://purl.uniprot.org/citations/33789099 | http://purl.uniprot.org/core/author | "Mondal D."xsd:string |
| http://purl.uniprot.org/citations/33789099 | http://purl.uniprot.org/core/author | "Serra P."xsd:string |
| http://purl.uniprot.org/citations/33789099 | http://purl.uniprot.org/core/author | "Yamanouchi J."xsd:string |
| http://purl.uniprot.org/citations/33789099 | http://purl.uniprot.org/core/author | "Uddin M.M."xsd:string |
| http://purl.uniprot.org/citations/33789099 | http://purl.uniprot.org/core/author | "Umeshappa C.S."xsd:string |
| http://purl.uniprot.org/citations/33789099 | http://purl.uniprot.org/core/author | "Singha S."xsd:string |
| http://purl.uniprot.org/citations/33789099 | http://purl.uniprot.org/core/author | "Surewaard B.G.J."xsd:string |
| http://purl.uniprot.org/citations/33789099 | http://purl.uniprot.org/core/author | "Sole P."xsd:string |
| http://purl.uniprot.org/citations/33789099 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33789099 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/33789099 | http://purl.uniprot.org/core/pages | "108919"xsd:string |
| http://purl.uniprot.org/citations/33789099 | http://purl.uniprot.org/core/title | "Liver-specific T regulatory type-1 cells program local neutrophils to suppress hepatic autoimmunity via CRAMP."xsd:string |
| http://purl.uniprot.org/citations/33789099 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/33789099 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33789099 |
| http://purl.uniprot.org/citations/33789099 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33789099 |