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| http://purl.uniprot.org/citations/33790322 | http://www.w3.org/2000/01/rdf-schema#comment | "Activating transcription factor 5 (ATF5) is a member of the cAMP response element binding protein (CREB)/ATF family of basic leucine zipper transcription factors. We previously reported that ATF5-deficient (ATF5-/-) mice exhibited behavioural abnormalities, including abnormal social interactions, reduced behavioural flexibility, increased anxiety-like behaviours, and hyperactivity in novel environments. ATF5-/- mice may therefore be a useful animal model for psychiatric disorders. ATF5 is highly expressed in the ventricular zone and subventricular zone during cortical development, but its physiological role in higher-order brain structures remains unknown. To investigate the cause of abnormal behaviours exhibited by ATF5-/- mice, we analysed the embryonic cerebral cortex of ATF5-/- mice. The ATF5-/- embryonic cerebral cortex was slightly thinner and had reduced numbers of radial glial cells and neural progenitor cells, compared to a wild-type cerebral cortex. ATF5 deficiency also affected the basal processes of radial glial cells, which serve as a scaffold for radial migration during cortical development. Further, the radial migration of cortical upper layer neurons was impaired in ATF5-/- mice. These results suggest that ATF5 deficiency affects cortical development and radial migration, which may partly contribute to the observed abnormal behaviours."xsd:string |
| http://purl.uniprot.org/citations/33790322 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-021-86442-5"xsd:string |
| http://purl.uniprot.org/citations/33790322 | http://purl.uniprot.org/core/author | "Takahashi Y."xsd:string |
| http://purl.uniprot.org/citations/33790322 | http://purl.uniprot.org/core/author | "Kaneko Y."xsd:string |
| http://purl.uniprot.org/citations/33790322 | http://purl.uniprot.org/core/author | "Umemura M."xsd:string |
| http://purl.uniprot.org/citations/33790322 | http://purl.uniprot.org/core/author | "Tanabe R."xsd:string |
| http://purl.uniprot.org/citations/33790322 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33790322 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/33790322 | http://purl.uniprot.org/core/pages | "7295"xsd:string |
| http://purl.uniprot.org/citations/33790322 | http://purl.uniprot.org/core/title | "ATF5 deficiency causes abnormal cortical development."xsd:string |
| http://purl.uniprot.org/citations/33790322 | http://purl.uniprot.org/core/volume | "11"xsd:string |
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