| http://purl.uniprot.org/citations/33799807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33799807 | http://www.w3.org/2000/01/rdf-schema#comment | "ADP-ribosylation is a post-translational protein modification catalyzed by a family of proteins known as poly-ADP-ribose polymerases. PARP7 (TIPARP; ARTD14) is a mono-ADP-ribosyltransferase involved in several cellular processes, including responses to hypoxia, innate immunity and regulation of nuclear receptors. Since previous studies suggested that PARP7 was regulated by 17β-estradiol, we investigated whether PARP7 regulates estrogen receptor α signaling. We confirmed the 17β-estradiol-dependent increases of PARP7 mRNA and protein levels in MCF-7 cells, and observed recruitment of estrogen receptor α to the promoter of PARP7. Overexpression of PARP7 decreased ligand-dependent estrogen receptor α signaling, while treatment of PARP7 knockout MCF-7 cells with 17β-estradiol resulted in increased expression of and recruitment to estrogen receptor α target genes, in addition to increased proliferation. Co-immunoprecipitation assays revealed that PARP7 mono-ADP-ribosylated estrogen receptor α, and mass spectrometry mapped the modified peptides to the receptor's ligand-independent transactivation domain. Co-immunoprecipitation with truncated estrogen receptor α variants identified that the hinge region of the receptor is required for PARP7-dependent mono-ADP-ribosylation. These results imply that PARP7-mediated mono-ADP-ribosylation may play an important role in estrogen receptor positive breast cancer."xsd:string |
| http://purl.uniprot.org/citations/33799807 | http://purl.org/dc/terms/identifier | "doi:10.3390/cells10030623"xsd:string |
| http://purl.uniprot.org/citations/33799807 | http://purl.uniprot.org/core/author | "Rasmussen M."xsd:string |
| http://purl.uniprot.org/citations/33799807 | http://purl.uniprot.org/core/author | "Moen A."xsd:string |
| http://purl.uniprot.org/citations/33799807 | http://purl.uniprot.org/core/author | "Tan S."xsd:string |
| http://purl.uniprot.org/citations/33799807 | http://purl.uniprot.org/core/author | "Anonsen J.H."xsd:string |
| http://purl.uniprot.org/citations/33799807 | http://purl.uniprot.org/core/author | "Grant D.M."xsd:string |
| http://purl.uniprot.org/citations/33799807 | http://purl.uniprot.org/core/author | "Hutin D."xsd:string |
| http://purl.uniprot.org/citations/33799807 | http://purl.uniprot.org/core/author | "Matthews J."xsd:string |
| http://purl.uniprot.org/citations/33799807 | http://purl.uniprot.org/core/author | "Somisetty V.S."xsd:string |
| http://purl.uniprot.org/citations/33799807 | http://purl.uniprot.org/core/author | "Olafsen N.E."xsd:string |
| http://purl.uniprot.org/citations/33799807 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33799807 | http://purl.uniprot.org/core/name | "Cells"xsd:string |
| http://purl.uniprot.org/citations/33799807 | http://purl.uniprot.org/core/pages | "623"xsd:string |
| http://purl.uniprot.org/citations/33799807 | http://purl.uniprot.org/core/title | "PARP7 and Mono-ADP-Ribosylation Negatively Regulate Estrogen Receptor alpha Signaling in Human Breast Cancer Cells."xsd:string |
| http://purl.uniprot.org/citations/33799807 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/33799807 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33799807 |
| http://purl.uniprot.org/citations/33799807 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33799807 |
| http://purl.uniprot.org/uniprot/#_A0A125SXW0-mappedCitation-33799807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33799807 |
| http://purl.uniprot.org/uniprot/#_A0A125SXW1-mappedCitation-33799807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33799807 |
| http://purl.uniprot.org/uniprot/#_A0A125SXV8-mappedCitation-33799807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33799807 |
| http://purl.uniprot.org/uniprot/#_A0A125SXV9-mappedCitation-33799807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33799807 |
| http://purl.uniprot.org/uniprot/#_A0A125SXW2-mappedCitation-33799807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33799807 |
| http://purl.uniprot.org/uniprot/#_A0A125SXW3-mappedCitation-33799807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33799807 |