| http://purl.uniprot.org/citations/33805672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33805672 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitochondrial fission and fusion cycles are integrated with cell cycle progression. Here we first re-visited how mitochondrial ETC inhibition disturbed mitosis progression, resulting in multipolar spindles formation in HeLa cells. Inhibitors of ETC complex I (rotenone, ROT) and complex III (antimycin A, AA) decreased the phosphorylation of Plk1 T210 and Aurora A T288 in the mitotic phase (M-phase), especially ROT, affecting the dynamic phosphorylation status of fission protein dynamin-related protein 1 (Drp1) and the Ser637/Ser616 ratio. We then tested whether specific Drp1 inhibitors, Mdivi-1 or Dynasore, affected the dynamic phosphorylation status of Drp1. Similar to the effects of ROT and AA, our results showed that Mdivi-1 but not Dynasore influenced the dynamic phosphorylation status of Ser637 and Ser616 in Drp1, which converged with mitotic kinases (Cdk1, Plk1, Aurora A) and centrosome-associated proteins to significantly accelerate mitotic defects. Moreover, our data also indicated that evoking mito-Drp1-Ser637 by protein kinase A (PKA) rather than Drp1-Ser616 by Cdk1/Cyclin B resulted in mitochondrial fission via the PINK1/Parkin pathway to promote more efficient mitophagy and simultaneously caused multipolar spindles. Collectively, this study is the first to uncover that mito-Drp1-Ser637 by PKA, but not Drp1-Ser616, drives mitophagy to exert multipolar spindles formation during M-phase."xsd:string |
| http://purl.uniprot.org/citations/33805672 | http://purl.org/dc/terms/identifier | "doi:10.3390/biom11030424"xsd:string |
| http://purl.uniprot.org/citations/33805672 | http://purl.uniprot.org/core/author | "Huang C.F."xsd:string |
| http://purl.uniprot.org/citations/33805672 | http://purl.uniprot.org/core/author | "Ko H.J."xsd:string |
| http://purl.uniprot.org/citations/33805672 | http://purl.uniprot.org/core/author | "Chuang T.H."xsd:string |
| http://purl.uniprot.org/citations/33805672 | http://purl.uniprot.org/core/author | "Wang C.H."xsd:string |
| http://purl.uniprot.org/citations/33805672 | http://purl.uniprot.org/core/author | "Cheng J.T."xsd:string |
| http://purl.uniprot.org/citations/33805672 | http://purl.uniprot.org/core/author | "Hong Y.R."xsd:string |
| http://purl.uniprot.org/citations/33805672 | http://purl.uniprot.org/core/author | "Loh J.K."xsd:string |
| http://purl.uniprot.org/citations/33805672 | http://purl.uniprot.org/core/author | "Tsai C.Y."xsd:string |
| http://purl.uniprot.org/citations/33805672 | http://purl.uniprot.org/core/author | "Lai Y.L."xsd:string |
| http://purl.uniprot.org/citations/33805672 | http://purl.uniprot.org/core/author | "Kwan A.L."xsd:string |
| http://purl.uniprot.org/citations/33805672 | http://purl.uniprot.org/core/author | "Chiou S.J."xsd:string |
| http://purl.uniprot.org/citations/33805672 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33805672 | http://purl.uniprot.org/core/name | "Biomolecules"xsd:string |
| http://purl.uniprot.org/citations/33805672 | http://purl.uniprot.org/core/pages | "424"xsd:string |
| http://purl.uniprot.org/citations/33805672 | http://purl.uniprot.org/core/title | "The Phosphorylation Status of Drp1-Ser637 by PKA in Mitochondrial Fission Modulates Mitophagy via PINK1/Parkin to Exert Multipolar Spindles Assembly during Mitosis."xsd:string |
| http://purl.uniprot.org/citations/33805672 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/33805672 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33805672 |
| http://purl.uniprot.org/citations/33805672 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33805672 |
| http://purl.uniprot.org/uniprot/#_D3JZW5-mappedCitation-33805672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33805672 |
| http://purl.uniprot.org/uniprot/#_D3K2X1-mappedCitation-33805672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33805672 |
| http://purl.uniprot.org/uniprot/#_D3K2X2-mappedCitation-33805672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33805672 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z446-mappedCitation-33805672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33805672 |