| http://purl.uniprot.org/citations/33809261 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33809261 | http://www.w3.org/2000/01/rdf-schema#comment | "Lipin2 is a phosphatidate phosphatase that plays critical roles in fat homeostasis. Alterations in Lpin2, which encodes lipin2, cause the autoinflammatory bone disorder Majeed syndrome. Lipin2 limits lipopolysaccharide (LPS)-induced inflammatory responses in macrophages. However, little is known about the precise molecular mechanisms underlying its anti-inflammatory function. In this study, we attempted to elucidate the molecular link between the loss of lipin2 function and autoinflammatory bone disorder. Using a Lpin2 knockout murine macrophage cell line, we showed that lipin2 deficiency enhances innate immune responses to LPS stimulation through excessive activation of the NF-κB signaling pathway, partly because of TAK1 signaling upregulation. Lipin2 depletion also enhanced RANKL-mediated osteoclastogenesis and osteoclastic resorption activity accompanied by NFATc1 dephosphorylation and increased nuclear accumulation. These results suggest that lipin2 suppresses the development of autoinflammatory bone disorder by fine-tuning proinflammatory responses and osteoclastogenesis in macrophages. Therefore, this study provides insights into the molecular pathogenesis of monogenic autoinflammatory bone disorders and presents a potential therapeutic intervention."xsd:string |
| http://purl.uniprot.org/citations/33809261 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms22062893"xsd:string |
| http://purl.uniprot.org/citations/33809261 | http://purl.uniprot.org/core/author | "Inuzuka H."xsd:string |
| http://purl.uniprot.org/citations/33809261 | http://purl.uniprot.org/core/author | "Watahiki A."xsd:string |
| http://purl.uniprot.org/citations/33809261 | http://purl.uniprot.org/core/author | "Fukumoto S."xsd:string |
| http://purl.uniprot.org/citations/33809261 | http://purl.uniprot.org/core/author | "Chiba M."xsd:string |
| http://purl.uniprot.org/citations/33809261 | http://purl.uniprot.org/core/author | "Egusa H."xsd:string |
| http://purl.uniprot.org/citations/33809261 | http://purl.uniprot.org/core/author | "Hoshikawa S."xsd:string |
| http://purl.uniprot.org/citations/33809261 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33809261 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/33809261 | http://purl.uniprot.org/core/pages | "2893"xsd:string |
| http://purl.uniprot.org/citations/33809261 | http://purl.uniprot.org/core/title | "Deficiency of Lipin2 Results in Enhanced NF-kappaB Signaling and Osteoclast Formation in RAW-D Murine Macrophages."xsd:string |
| http://purl.uniprot.org/citations/33809261 | http://purl.uniprot.org/core/volume | "22"xsd:string |
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