| http://purl.uniprot.org/citations/33821003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33821003 | http://www.w3.org/2000/01/rdf-schema#comment | "Parental epigenomes are established during gametogenesis. While they are largely reset after fertilization, broad domains of Polycomb repressive complex 2 (PRC2)-mediated formation of lysine 27-trimethylated histone H3 (H3K27me3) are inherited from oocytes in mice. How maternal H3K27me3 is established and inherited by embryos remains elusive. Here, we show that PRC1-mediated formation of lysine 119-monoubiquititinated histone H2A (H2AK119ub1) confers maternally heritable H3K27me3. Temporal profiling of H2AK119ub1 dynamics revealed that atypically broad H2AK119ub1 domains are established, along with H3K27me3, during oocyte growth. From the two-cell stage, H2AK119ub1 is progressively deposited at typical Polycomb targets and precedes H3K27me3. Reduction of H2AK119ub1 by depletion of Polycomb group ring finger 1 (PCGF1) and PCGF6-essential components of variant PRC1 (vPRC1)-leads to H3K27me3 loss at a subset of genes in oocytes. The gene-selective H3K27me3 deficiency is irreversibly inherited by embryos, causing loss of maternal H3K27me3-dependent imprinting, embryonic sublethality and placental enlargement at term. Collectively, our study unveils preceding dynamics of H2AK119ub1 over H3K27me3 at the maternal-to-zygotic transition, and identifies PCGF1/6-vPRC1 as an essential player in maternal epigenetic inheritance."xsd:string |
| http://purl.uniprot.org/citations/33821003 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41588-021-00820-3"xsd:string |
| http://purl.uniprot.org/citations/33821003 | http://purl.uniprot.org/core/author | "Inoue A."xsd:string |
| http://purl.uniprot.org/citations/33821003 | http://purl.uniprot.org/core/author | "Koseki H."xsd:string |
| http://purl.uniprot.org/citations/33821003 | http://purl.uniprot.org/core/author | "Hayashi R."xsd:string |
| http://purl.uniprot.org/citations/33821003 | http://purl.uniprot.org/core/author | "Mei H."xsd:string |
| http://purl.uniprot.org/citations/33821003 | http://purl.uniprot.org/core/author | "Kumon M."xsd:string |
| http://purl.uniprot.org/citations/33821003 | http://purl.uniprot.org/core/author | "Kozuka C."xsd:string |
| http://purl.uniprot.org/citations/33821003 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33821003 | http://purl.uniprot.org/core/name | "Nat Genet"xsd:string |
| http://purl.uniprot.org/citations/33821003 | http://purl.uniprot.org/core/pages | "539-550"xsd:string |
| http://purl.uniprot.org/citations/33821003 | http://purl.uniprot.org/core/title | "H2AK119ub1 guides maternal inheritance and zygotic deposition of H3K27me3 in mouse embryos."xsd:string |
| http://purl.uniprot.org/citations/33821003 | http://purl.uniprot.org/core/volume | "53"xsd:string |
| http://purl.uniprot.org/citations/33821003 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33821003 |
| http://purl.uniprot.org/citations/33821003 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33821003 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J141-mappedCitation-33821003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33821003 |
| http://purl.uniprot.org/uniprot/#_A0A2Z6DUK5-mappedCitation-33821003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33821003 |
| http://purl.uniprot.org/uniprot/#_A0A494B9Z3-mappedCitation-33821003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33821003 |
| http://purl.uniprot.org/uniprot/#_A0A2I6EDI9-mappedCitation-33821003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33821003 |
| http://purl.uniprot.org/uniprot/#_A0A2I6EDJ6-mappedCitation-33821003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33821003 |
| http://purl.uniprot.org/uniprot/#_G3UZG9-mappedCitation-33821003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33821003 |
| http://purl.uniprot.org/uniprot/#_E2JL30-mappedCitation-33821003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33821003 |
| http://purl.uniprot.org/uniprot/#_E2JL33-mappedCitation-33821003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33821003 |
| http://purl.uniprot.org/uniprot/#_E2JL35-mappedCitation-33821003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33821003 |