| http://purl.uniprot.org/citations/33824334 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33824334 | http://www.w3.org/2000/01/rdf-schema#comment | "The Drosophila tumour necrosis factor (TNF) ligand-receptor system consists of a unique ligand, Eiger (Egr), and two receptors, Grindelwald (Grnd) and Wengen (Wgn), and therefore provides a simple system for exploring the interplay between ligand and receptors, and the requirement for Grnd and Wgn in TNF/Egr-mediated processes. Here, we report the crystallographic structure of the extracellular domain (ECD) of Grnd in complex with Egr, a high-affinity hetero-hexameric assembly reminiscent of human TNF:TNFR complexes. We show that ectopic expression of Egr results in internalisation of Egr:Grnd complexes in vesicles, a step preceding and strictly required for Egr-induced apoptosis. We further demonstrate that Wgn binds Egr with much reduced affinity and is localised in intracellular vesicles that are distinct from those containing Egr:Grnd complexes. Altogether, our data provide insight into ligand-mediated activation of Grnd and suggest that distinct affinities of TNF ligands for their receptors promote different and non-redundant cellular functions."xsd:string |
| http://purl.uniprot.org/citations/33824334 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-021-22080-9"xsd:string |
| http://purl.uniprot.org/citations/33824334 | http://purl.uniprot.org/core/author | "Mapelli M."xsd:string |
| http://purl.uniprot.org/citations/33824334 | http://purl.uniprot.org/core/author | "Andersen D.S."xsd:string |
| http://purl.uniprot.org/citations/33824334 | http://purl.uniprot.org/core/author | "Pasqualato S."xsd:string |
| http://purl.uniprot.org/citations/33824334 | http://purl.uniprot.org/core/author | "Olieric V."xsd:string |
| http://purl.uniprot.org/citations/33824334 | http://purl.uniprot.org/core/author | "Mari S."xsd:string |
| http://purl.uniprot.org/citations/33824334 | http://purl.uniprot.org/core/author | "Colombani J."xsd:string |
| http://purl.uniprot.org/citations/33824334 | http://purl.uniprot.org/core/author | "Palmerini V."xsd:string |
| http://purl.uniprot.org/citations/33824334 | http://purl.uniprot.org/core/author | "Monzani S."xsd:string |
| http://purl.uniprot.org/citations/33824334 | http://purl.uniprot.org/core/author | "Cecatiello V."xsd:string |
| http://purl.uniprot.org/citations/33824334 | http://purl.uniprot.org/core/author | "Loudhaief R."xsd:string |
| http://purl.uniprot.org/citations/33824334 | http://purl.uniprot.org/core/author | "Laurichesse Q."xsd:string |
| http://purl.uniprot.org/citations/33824334 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33824334 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/33824334 | http://purl.uniprot.org/core/pages | "2070"xsd:string |
| http://purl.uniprot.org/citations/33824334 | http://purl.uniprot.org/core/title | "Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions."xsd:string |
| http://purl.uniprot.org/citations/33824334 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/33824334 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33824334 |
| http://purl.uniprot.org/citations/33824334 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33824334 |
| http://purl.uniprot.org/uniprot/Q8MUJ1#attribution-171C1CF989C029414311A3E8A279F69B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/33824334 |
| http://purl.uniprot.org/uniprot/Q9VJ83#attribution-171C1CF989C029414311A3E8A279F69B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/33824334 |
| http://purl.uniprot.org/uniprot/Q9VJ83#attribution-1CC1BE8B6B067BFC92086E073F6CFCC4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/33824334 |
| http://purl.uniprot.org/uniprot/Q9VWS4#attribution-171C1CF989C029414311A3E8A279F69B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/33824334 |