| http://purl.uniprot.org/citations/33836007 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33836007 | http://www.w3.org/2000/01/rdf-schema#comment | "Stromal elastosis is related to good prognosis in breast cancer and fibulin-2 helps to stabilize elastic fibers in basement membranes. Here, we examined the level of perivascular fibulin-2 expression in relation to elastosis content, vascular invasion, molecular subtypes, tumour detection mode, and patient prognosis in breast cancer. We performed a population based retrospective study of invasive breast cancers from the Norwegian Breast Screening Program (Vestfold County, 2004-2009) including 200 screen-detected and 82 interval cancers. Perivascular fibulin-2 staining was semi-quantitatively graded based on immunohistochemistry (1-3) and dichotomized as high expression (grade 2-3) and low expression (grade 1). Elastosis content was graded on a 4-tiered scale and dichotomized as high (score 3) and low (score 0-2) expression, whereas lymphatic (LVI) and blood vessel invasion (BVI) were recorded as absent or present by immunohistochemistry. High perivascular fibulin-2 expression was strongly related to stromal elastosis (p<0.001), and inversely associated with BVI and LVI (p<0.001 for both). High fibulin-2 was associated with luminal breast cancer subgroups (p<0.001) and inversely with interval cancers compared with screen-detected tumours (p<0.001). By univariate analysis, low perivascular fibulin-2 was associated with reduced recurrence-free survival (p = 0.002) and disease specific survival (p = 0.019). Low perivascular fibulin-2 expression was strongly related to vascular invasion, low stromal elastosis, non-luminal breast cancer subtypes, interval presentation, and adverse prognosis."xsd:string |
| http://purl.uniprot.org/citations/33836007 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0249767"xsd:string |
| http://purl.uniprot.org/citations/33836007 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/33836007 | http://purl.uniprot.org/core/author | "Akslen L.A."xsd:string |
| http://purl.uniprot.org/citations/33836007 | http://purl.uniprot.org/core/author | "Wik E."xsd:string |
| http://purl.uniprot.org/citations/33836007 | http://purl.uniprot.org/core/author | "Aas H."xsd:string |
| http://purl.uniprot.org/citations/33836007 | http://purl.uniprot.org/core/author | "Klingen T.A."xsd:string |
| http://purl.uniprot.org/citations/33836007 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33836007 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/33836007 | http://purl.uniprot.org/core/pages | "e0249767"xsd:string |
| http://purl.uniprot.org/citations/33836007 | http://purl.uniprot.org/core/title | "Fibulin-2 expression associates with vascular invasion and patient survival in breast cancer."xsd:string |
| http://purl.uniprot.org/citations/33836007 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/33836007 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33836007 |
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