| http://purl.uniprot.org/citations/33839281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33839281 | http://www.w3.org/2000/01/rdf-schema#comment | "Background & aimsIron has been proposed as influencing the progression of liver disease in subjects with non-alcoholic fatty liver disease (NAFLD). We have previously shown that, in the Hfe-/- mouse model of hemochromatosis, feeding of a high-calorie diet (HCD) leads to increased liver injury. In this study we investigated whether the feeding of an iron deficient/HCD to Hfe-/- mice influenced the development of NAFLD.MethodsLiver histology was assessed in Hfe-/- mice fed a standard iron-containing or iron-deficient diet plus or minus a HCD. Hepatic iron concentration, serum transferrin saturation and free fatty acid were measured. Expression of genes implicated in iron regulation and fatty liver disease was determined by quantitative real-time PCR (qRT-PCR).ResultsStandard iron/HCD-fed mice developed severe steatosis whereas NAS score was reduced in mice fed iron-deficient HCD. Mice fed iron-deficient HCD had lower liver weights, lower transferrin saturation and decreased ferroportin and hepcidin gene expression than HCD-fed mice. Serum non-esterified fatty acids were increased in iron-deficient HCD-fed mice compared with standard iron HCD. Expression analysis indicated that genes involved in fatty-acid binding and mTOR pathways were regulated by iron depletion.ConclusionsOur results indicate that decreasing iron intake attenuates the development of steatosis resulting from a high calorie diet. These results also suggest that human studies of agents that modify iron balance in patients with NAFLD should be revisited."xsd:string |
| http://purl.uniprot.org/citations/33839281 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbadis.2021.166142"xsd:string |
| http://purl.uniprot.org/citations/33839281 | http://purl.uniprot.org/core/author | "Subramaniam V.N."xsd:string |
| http://purl.uniprot.org/citations/33839281 | http://purl.uniprot.org/core/author | "Burke L.J."xsd:string |
| http://purl.uniprot.org/citations/33839281 | http://purl.uniprot.org/core/author | "Bridle K.R."xsd:string |
| http://purl.uniprot.org/citations/33839281 | http://purl.uniprot.org/core/author | "Jaskowski L.A."xsd:string |
| http://purl.uniprot.org/citations/33839281 | http://purl.uniprot.org/core/author | "Rishi G."xsd:string |
| http://purl.uniprot.org/citations/33839281 | http://purl.uniprot.org/core/author | "Briskey D."xsd:string |
| http://purl.uniprot.org/citations/33839281 | http://purl.uniprot.org/core/author | "Musgrave N."xsd:string |
| http://purl.uniprot.org/citations/33839281 | http://purl.uniprot.org/core/author | "Crawford D.H.G."xsd:string |
| http://purl.uniprot.org/citations/33839281 | http://purl.uniprot.org/core/author | "Britton L.J."xsd:string |
| http://purl.uniprot.org/citations/33839281 | http://purl.uniprot.org/core/author | "Ross D.G.F."xsd:string |
| http://purl.uniprot.org/citations/33839281 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33839281 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta Mol Basis Dis"xsd:string |
| http://purl.uniprot.org/citations/33839281 | http://purl.uniprot.org/core/pages | "166142"xsd:string |
| http://purl.uniprot.org/citations/33839281 | http://purl.uniprot.org/core/title | "Iron depletion attenuates steatosis in a mouse model of non-alcoholic fatty liver disease: Role of iron-dependent pathways."xsd:string |
| http://purl.uniprot.org/citations/33839281 | http://purl.uniprot.org/core/volume | "1867"xsd:string |
| http://purl.uniprot.org/citations/33839281 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33839281 |
| http://purl.uniprot.org/citations/33839281 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33839281 |
| http://purl.uniprot.org/uniprot/#_P70387-mappedCitation-33839281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33839281 |
| http://purl.uniprot.org/uniprot/#_F7CW53-mappedCitation-33839281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33839281 |
| http://purl.uniprot.org/uniprot/#_Q5SZ87-mappedCitation-33839281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33839281 |
| http://purl.uniprot.org/uniprot/#_Q5SZ91-mappedCitation-33839281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33839281 |
| http://purl.uniprot.org/uniprot/#_Q8R557-mappedCitation-33839281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33839281 |