| http://purl.uniprot.org/citations/33843075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33843075 | http://www.w3.org/2000/01/rdf-schema#comment | "As the most abundant internal modification of mRNA, N6 -methyladenosine (m6 A) methylation of RNA is emerging as a new layer of epitranscriptomic gene regulation in cellular processes, including embryo development, flowering-time control, microspore generation and fruit ripening, in plants. However, the cellular role of m6 A in plant responses to environmental stimuli remains largely unexplored. In this study, we show that m6 A methylation plays an important role in salt stress tolerance in Arabidopsis. All mutants of m6 A writer components, including MTA, MTB, VIRILIZER (VIR) and HAKAI, displayed salt-sensitive phenotypes in an m6 A-dependent manner. The vir mutant, in which the level of m6 A was most highly reduced, exhibited salt-hypersensitive phenotypes. Analysis of the m6 A methylome in the vir mutant revealed a transcriptome-wide loss of m6 A modification in the 3' untranslated region (3'-UTR). We demonstrated further that VIR-mediated m6 A methylation modulates reactive oxygen species homeostasis by negatively regulating the mRNA stability of several salt stress negative regulators, including ATAF1, GI and GSTU17, through affecting 3'-UTR lengthening linked to alternative polyadenylation. Our results highlight the important role played by epitranscriptomic mRNA methylation in the salt stress response of Arabidopsis and indicate a strong link between m6 A methylation and 3'-UTR length and mRNA stability during stress adaptation."xsd:string |
| http://purl.uniprot.org/citations/33843075 | http://purl.org/dc/terms/identifier | "doi:10.1111/tpj.15270"xsd:string |
| http://purl.uniprot.org/citations/33843075 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/33843075 | http://purl.uniprot.org/core/author | "Kang H."xsd:string |
| http://purl.uniprot.org/citations/33843075 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/33843075 | http://purl.uniprot.org/core/author | "Hu J."xsd:string |
| http://purl.uniprot.org/citations/33843075 | http://purl.uniprot.org/core/author | "Lee K."xsd:string |
| http://purl.uniprot.org/citations/33843075 | http://purl.uniprot.org/core/author | "Xu T."xsd:string |
| http://purl.uniprot.org/citations/33843075 | http://purl.uniprot.org/core/author | "Park S.J."xsd:string |
| http://purl.uniprot.org/citations/33843075 | http://purl.uniprot.org/core/author | "Cai J."xsd:string |
| http://purl.uniprot.org/citations/33843075 | http://purl.uniprot.org/core/author | "Yun J.Y."xsd:string |
| http://purl.uniprot.org/citations/33843075 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33843075 | http://purl.uniprot.org/core/name | "Plant J"xsd:string |
| http://purl.uniprot.org/citations/33843075 | http://purl.uniprot.org/core/pages | "1759-1775"xsd:string |
| http://purl.uniprot.org/citations/33843075 | http://purl.uniprot.org/core/title | "N6 -Methyladenosine mRNA methylation is important for salt stress tolerance in Arabidopsis."xsd:string |
| http://purl.uniprot.org/citations/33843075 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/33843075 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33843075 |
| http://purl.uniprot.org/citations/33843075 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33843075 |
| http://purl.uniprot.org/uniprot/F4J8G7#attribution-13730EF4CF2939AE4896D28BF3E655CE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/33843075 |
| http://purl.uniprot.org/uniprot/F4J8G7#attribution-2BE915E8A07BC27751A9654788F8AC62 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/33843075 |
| http://purl.uniprot.org/uniprot/#_F4J8G7-mappedCitation-33843075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33843075 |
| http://purl.uniprot.org/uniprot/#_Q39013-mappedCitation-33843075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33843075 |
| http://purl.uniprot.org/uniprot/#_Q2HIR8-mappedCitation-33843075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33843075 |
| http://purl.uniprot.org/uniprot/#_Q68KJ4-mappedCitation-33843075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33843075 |