| http://purl.uniprot.org/citations/33846855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33846855 | http://www.w3.org/2000/01/rdf-schema#comment | "Severe bleeding is a major cause of death in acute leukemia (AL) patients with graft-versus-host disease (GVHD) after allogene hematopoietic stem-cell transplantation (allo-HSCT). However, the prognostic value and prediction of HSCT-associated severe bleeding in GVHD patients have not been reported in cohort studies. We did a retrospective analysis of 200 AL patients with GVHD after allo-HSCT from Feb 1, 2014, to Dec 1, 2015. Multivariate analysis showed that the severe bleeding class was associated with the risk of death (HR 2.26, 95% CI 1.31-3.92, p<0.001***). In order to predict severe bleeding and figure out the solution to bleeding events, we established a multiple logistic regression model. HLA-DQB1 unmatching, megakaryocyte reconsititution failure, and III or IV GVHD were the independent risk factors for severe bleeding. Among all the variations above, OR of HLA-DQB1 was the highest (OR: 16.02, 95% CI: 11.54-48.68). Adding HLA-DQB1 to other factors improved the reclassification for predicting severe bleeding (NRI=0.195, z=2.634, p=0.008**; IDI=0.289, z=3.249, p<0.001***). Lasso regression was used to select variants. A nomogram of the logistic model was generated and displayed. Calibration curve demonstrated excellent accuracy in estimating severe bleeding (C index of 0.935). HLA-DQB1 showed excellent efficacy of predicting severe bleeding in HSCT patients."xsd:string |
| http://purl.uniprot.org/citations/33846855 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00277-021-04520-0"xsd:string |
| http://purl.uniprot.org/citations/33846855 | http://purl.uniprot.org/core/author | "Han Y."xsd:string |
| http://purl.uniprot.org/citations/33846855 | http://purl.uniprot.org/core/author | "Qi J."xsd:string |
| http://purl.uniprot.org/citations/33846855 | http://purl.uniprot.org/core/author | "Wu D."xsd:string |
| http://purl.uniprot.org/citations/33846855 | http://purl.uniprot.org/core/author | "Pan T."xsd:string |
| http://purl.uniprot.org/citations/33846855 | http://purl.uniprot.org/core/author | "Tang Y."xsd:string |
| http://purl.uniprot.org/citations/33846855 | http://purl.uniprot.org/core/author | "Shen W."xsd:string |
| http://purl.uniprot.org/citations/33846855 | http://purl.uniprot.org/core/author | "Zhang R."xsd:string |
| http://purl.uniprot.org/citations/33846855 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/33846855 | http://purl.uniprot.org/core/author | "Zhou M."xsd:string |
| http://purl.uniprot.org/citations/33846855 | http://purl.uniprot.org/core/author | "Cai C."xsd:string |
| http://purl.uniprot.org/citations/33846855 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33846855 | http://purl.uniprot.org/core/name | "Ann Hematol"xsd:string |
| http://purl.uniprot.org/citations/33846855 | http://purl.uniprot.org/core/pages | "2351-2361"xsd:string |
| http://purl.uniprot.org/citations/33846855 | http://purl.uniprot.org/core/title | "HLA-DQB1 mismatch increase risk of severe bleeding independently in recipients of allogeneic stem cell transplant."xsd:string |
| http://purl.uniprot.org/citations/33846855 | http://purl.uniprot.org/core/volume | "100"xsd:string |
| http://purl.uniprot.org/citations/33846855 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33846855 |
| http://purl.uniprot.org/citations/33846855 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33846855 |
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| http://purl.uniprot.org/uniprot/#_A0A0E3DC99-mappedCitation-33846855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33846855 |
| http://purl.uniprot.org/uniprot/#_A0A076L4M5-mappedCitation-33846855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33846855 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C7I5-mappedCitation-33846855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33846855 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C853-mappedCitation-33846855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33846855 |