| http://purl.uniprot.org/citations/33852723 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33852723 | http://www.w3.org/2000/01/rdf-schema#comment | "Insulin and insulin-like growth factors play important roles in carcinogenesis. Circulating insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein-3 (IGFBP-3) have been linked to cancer susceptibility. The associations of circulating IGF-1 and IGFBP-3 with the risk of renal cell carcinoma (RCC) are inconsistent. Recent large genome-wide association studies have identified 413 single nucleotide polymorphisms (SNPs) associated with IGF-1 and 4 SNPs associated with IGFBP-3. In this large case-control study consisting of 2069 RCC patients and 2052 healthy controls of European ancestry, we used a two-sample Mendelian randomization (MR) approach to investigate the associations of genetically predicted circulating IGF-1 and IGFBP-3 with RCC risk. We used an individual level data-based genetic risk score (GRS) and a summary statistics-based inverse-variance weighting (IVW) method in MR analyses. We found that genetically predicted IGF-1 was significantly associated with RCC risk in both the GRS analysis [odds ratio (OR) = 0.43 per SD increase, 95% confidence interval (CI), 0.34-0.53] and the IVW analysis (OR = 0.46 per SD increase, 95% CI, 0.37-0.57). Dichotomized at the median GRS value of IGF-1 in controls, individuals with high GRS had a 45% reduced RCC risk (OR = 0.55, 95% CI, 0.48-0.62) compared with those with low GRS. Genetically predicted circulating IGFBP-3 was not associated with RCC risk. This is the largest RCC study of circulating IGF-1 and IGFBP-3 to date and our data suggest a strong inverse relationship between circulating IGF-1 level and RCC risk."xsd:string |
| http://purl.uniprot.org/citations/33852723 | http://purl.org/dc/terms/identifier | "doi:10.1093/carcin/bgab031"xsd:string |
| http://purl.uniprot.org/citations/33852723 | http://purl.uniprot.org/core/author | "Chen M."xsd:string |
| http://purl.uniprot.org/citations/33852723 | http://purl.uniprot.org/core/author | "Gu J."xsd:string |
| http://purl.uniprot.org/citations/33852723 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/33852723 | http://purl.uniprot.org/core/author | "Tsai C.W."xsd:string |
| http://purl.uniprot.org/citations/33852723 | http://purl.uniprot.org/core/author | "Xiong G.Y."xsd:string |
| http://purl.uniprot.org/citations/33852723 | http://purl.uniprot.org/core/author | "Chang W.S."xsd:string |
| http://purl.uniprot.org/citations/33852723 | http://purl.uniprot.org/core/author | "Bau D.T."xsd:string |
| http://purl.uniprot.org/citations/33852723 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33852723 | http://purl.uniprot.org/core/name | "Carcinogenesis"xsd:string |
| http://purl.uniprot.org/citations/33852723 | http://purl.uniprot.org/core/pages | "826-830"xsd:string |
| http://purl.uniprot.org/citations/33852723 | http://purl.uniprot.org/core/title | "High circulating insulin-like growth factor-1 reduces the risk of renal cell carcinoma: a Mendelian randomization study."xsd:string |
| http://purl.uniprot.org/citations/33852723 | http://purl.uniprot.org/core/volume | "42"xsd:string |
| http://purl.uniprot.org/citations/33852723 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33852723 |
| http://purl.uniprot.org/citations/33852723 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33852723 |
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| http://purl.uniprot.org/uniprot/#_A6XND1-mappedCitation-33852723 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33852723 |
| http://purl.uniprot.org/uniprot/#_B4DP07-mappedCitation-33852723 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33852723 |