| http://purl.uniprot.org/citations/33852835 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33852835 | http://www.w3.org/2000/01/rdf-schema#comment | "The assembly pathways of mitochondrial respirasome (supercomplex I+III2+IV) are not fully understood. Here, we show that an early sub-complex I assembly, rather than holo-complex I, is sufficient to initiate mitochondrial respirasome assembly. We find that a distal part of the membrane arm of complex I (PD-a module) is a scaffold for the incorporation of complexes III and IV to form a respirasome subcomplex. Depletion of PD-a, rather than other complex I modules, decreases the steady-state levels of complexes III and IV. Both HEK293T cells lacking TIMMDC1 and patient-derived cells with disease-causing mutations in TIMMDC1 showed accumulation of this respirasome subcomplex. This suggests that TIMMDC1, previously known as a complex-I assembly factor, may function as a respirasome assembly factor. Collectively, we provide a detailed, cooperative assembly model in which most complex-I subunits are added to the respirasome subcomplex in the lateral stages of respirasome assembly."xsd:string |
| http://purl.uniprot.org/citations/33852835 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2021.108963"xsd:string |
| http://purl.uniprot.org/citations/33852835 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/33852835 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/33852835 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/33852835 | http://purl.uniprot.org/core/author | "Lin Z."xsd:string |
| http://purl.uniprot.org/citations/33852835 | http://purl.uniprot.org/core/author | "Jia M."xsd:string |
| http://purl.uniprot.org/citations/33852835 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/33852835 | http://purl.uniprot.org/core/author | "Yang Y.'"xsd:string |
| http://purl.uniprot.org/citations/33852835 | http://purl.uniprot.org/core/author | "Zhao Q."xsd:string |
| http://purl.uniprot.org/citations/33852835 | http://purl.uniprot.org/core/author | "Zhu J."xsd:string |
| http://purl.uniprot.org/citations/33852835 | http://purl.uniprot.org/core/author | "Xie J."xsd:string |
| http://purl.uniprot.org/citations/33852835 | http://purl.uniprot.org/core/author | "Fang H."xsd:string |
| http://purl.uniprot.org/citations/33852835 | http://purl.uniprot.org/core/author | "Bao X."xsd:string |
| http://purl.uniprot.org/citations/33852835 | http://purl.uniprot.org/core/author | "Han Q."xsd:string |
| http://purl.uniprot.org/citations/33852835 | http://purl.uniprot.org/core/author | "Ye X."xsd:string |
| http://purl.uniprot.org/citations/33852835 | http://purl.uniprot.org/core/author | "Lyu J."xsd:string |
| http://purl.uniprot.org/citations/33852835 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33852835 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/33852835 | http://purl.uniprot.org/core/pages | "108963"xsd:string |
| http://purl.uniprot.org/citations/33852835 | http://purl.uniprot.org/core/title | "A membrane arm of mitochondrial complex I sufficient to promote respirasome formation."xsd:string |
| http://purl.uniprot.org/citations/33852835 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/33852835 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33852835 |
| http://purl.uniprot.org/citations/33852835 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33852835 |