| http://purl.uniprot.org/citations/33870126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33870126 | http://www.w3.org/2000/01/rdf-schema#comment | "Androgens have a robust effect on skeletal muscles to increase muscle mass and strength. The molecular mechanism of androgen/androgen receptor (AR) action on muscle strength is still not well known, especially for the regulation of sarcomeric genes. In this study, we generated androgen-induced hypertrophic model mice, myofiber-specific androgen receptor knockout (cARKO) mice supplemented with dihydrotestosterone (DHT). DHT treatment increased grip strength in control mice but not in cARKO mice. Transcriptome analysis by RNA-seq, using skeletal muscles obtained from control and cARKO mice treated with or without DHT, identified a fast-type muscle-specific novel splicing variant of Myosin light-chain kinase 4 (Mylk4) as a target of AR in skeletal muscles. Mylk4 knockout mice exhibited decreased maximum isometric torque of plantar flexion and passive stiffness of myofibers due to reduced phosphorylation of Myomesin 1 protein. This study suggests that androgen-induced skeletal muscle strength is mediated with Mylk4 and Myomesin 1 axis."xsd:string |
| http://purl.uniprot.org/citations/33870126 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.isci.2021.102303"xsd:string |
| http://purl.uniprot.org/citations/33870126 | http://purl.uniprot.org/core/author | "Hirakawa H."xsd:string |
| http://purl.uniprot.org/citations/33870126 | http://purl.uniprot.org/core/author | "Imai Y."xsd:string |
| http://purl.uniprot.org/citations/33870126 | http://purl.uniprot.org/core/author | "Sakai H."xsd:string |
| http://purl.uniprot.org/citations/33870126 | http://purl.uniprot.org/core/author | "Takahashi H."xsd:string |
| http://purl.uniprot.org/citations/33870126 | http://purl.uniprot.org/core/author | "Sawada Y."xsd:string |
| http://purl.uniprot.org/citations/33870126 | http://purl.uniprot.org/core/author | "Yokoyama A."xsd:string |
| http://purl.uniprot.org/citations/33870126 | http://purl.uniprot.org/core/author | "Yamada T."xsd:string |
| http://purl.uniprot.org/citations/33870126 | http://purl.uniprot.org/core/author | "Sawasaki T."xsd:string |
| http://purl.uniprot.org/citations/33870126 | http://purl.uniprot.org/core/author | "Yanagihara Y."xsd:string |
| http://purl.uniprot.org/citations/33870126 | http://purl.uniprot.org/core/author | "Sakakibara I."xsd:string |
| http://purl.uniprot.org/citations/33870126 | http://purl.uniprot.org/core/author | "Saeki N."xsd:string |
| http://purl.uniprot.org/citations/33870126 | http://purl.uniprot.org/core/author | "Fukada S.I."xsd:string |
| http://purl.uniprot.org/citations/33870126 | http://purl.uniprot.org/core/author | "Himori K."xsd:string |
| http://purl.uniprot.org/citations/33870126 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33870126 | http://purl.uniprot.org/core/name | "iScience"xsd:string |
| http://purl.uniprot.org/citations/33870126 | http://purl.uniprot.org/core/pages | "102303"xsd:string |
| http://purl.uniprot.org/citations/33870126 | http://purl.uniprot.org/core/title | "Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk4."xsd:string |
| http://purl.uniprot.org/citations/33870126 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/33870126 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33870126 |
| http://purl.uniprot.org/citations/33870126 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33870126 |
| http://purl.uniprot.org/uniprot/#_A0A5F8MPR5-mappedCitation-33870126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33870126 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VI35-mappedCitation-33870126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33870126 |