| http://purl.uniprot.org/citations/33875620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33875620 | http://www.w3.org/2000/01/rdf-schema#comment | "Pentraxins are a family of evolutionarily conserved pattern recognition molecules with pivotal roles in innate immunity and inflammation, such as opsonization of pathogens during bacterial and viral infections. In particular, the long Pentraxin 3 (PTX3) has been shown to regulate several aspects of vascular and tissue inflammation during solid organ transplantation. Our study investigated the role of PTX3 as possible modulator of Complement activation in a swine model of renal ischemia/reperfusion (I/R) injury. We demonstrated that I/R injury induced early PTX3 deposits at peritubular and glomerular capillary levels. Confocal laser scanning microscopy revealed PTX3 deposits co-localizing with CD31+ endothelial cells. In addition, PTX3 was associated with infiltrating macrophages (CD163), dendritic cells (SWC3a) and myofibroblasts (FSP1). In particular, we demonstrated a significant PTX3-mediated activation of classical (C1q-mediated) and lectin (MBL-mediated) pathways of Complement. Interestingly, PTX3 deposits co-localized with activation of the terminal Complement complex (C5b-9) on endothelial cells, indicating that PTX3-mediated Complement activation occurred mainly at the renal vascular level. In conclusion, these data indicate that PTX3 might be a potential therapeutic target to prevent Complement-induced I/R injury."xsd:string |
| http://purl.uniprot.org/citations/33875620 | http://purl.org/dc/terms/identifier | "doi:10.18632/aging.202992"xsd:string |
| http://purl.uniprot.org/citations/33875620 | http://purl.uniprot.org/core/author | "Daha M.R."xsd:string |
| http://purl.uniprot.org/citations/33875620 | http://purl.uniprot.org/core/author | "van Kooten C."xsd:string |
| http://purl.uniprot.org/citations/33875620 | http://purl.uniprot.org/core/author | "Gesualdo L."xsd:string |
| http://purl.uniprot.org/citations/33875620 | http://purl.uniprot.org/core/author | "Grandaliano G."xsd:string |
| http://purl.uniprot.org/citations/33875620 | http://purl.uniprot.org/core/author | "Ranieri E."xsd:string |
| http://purl.uniprot.org/citations/33875620 | http://purl.uniprot.org/core/author | "Battaglia M."xsd:string |
| http://purl.uniprot.org/citations/33875620 | http://purl.uniprot.org/core/author | "Divella C."xsd:string |
| http://purl.uniprot.org/citations/33875620 | http://purl.uniprot.org/core/author | "Rossini M."xsd:string |
| http://purl.uniprot.org/citations/33875620 | http://purl.uniprot.org/core/author | "Lucarelli G."xsd:string |
| http://purl.uniprot.org/citations/33875620 | http://purl.uniprot.org/core/author | "Pontrelli P."xsd:string |
| http://purl.uniprot.org/citations/33875620 | http://purl.uniprot.org/core/author | "Castellano G."xsd:string |
| http://purl.uniprot.org/citations/33875620 | http://purl.uniprot.org/core/author | "Netti G.S."xsd:string |
| http://purl.uniprot.org/citations/33875620 | http://purl.uniprot.org/core/author | "Stallone G."xsd:string |
| http://purl.uniprot.org/citations/33875620 | http://purl.uniprot.org/core/author | "Sallustio F."xsd:string |
| http://purl.uniprot.org/citations/33875620 | http://purl.uniprot.org/core/author | "Ditonno P."xsd:string |
| http://purl.uniprot.org/citations/33875620 | http://purl.uniprot.org/core/author | "van der Pol P."xsd:string |
| http://purl.uniprot.org/citations/33875620 | http://purl.uniprot.org/core/author | "Franzin R."xsd:string |
| http://purl.uniprot.org/citations/33875620 | http://purl.uniprot.org/core/author | "Staffieri F."xsd:string |
| http://purl.uniprot.org/citations/33875620 | http://purl.uniprot.org/core/author | "Stasi A."xsd:string |
| http://purl.uniprot.org/citations/33875620 | http://purl.uniprot.org/core/author | "Crovace A.M."xsd:string |
| http://purl.uniprot.org/citations/33875620 | http://purl.uniprot.org/core/author | "Lacitignola L."xsd:string |
| http://purl.uniprot.org/citations/33875620 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |