| http://purl.uniprot.org/citations/33878293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33878293 | http://www.w3.org/2000/01/rdf-schema#comment | "Even though SYK and ZAP70 kinases share high sequence homology and serve analogous functions, their expression in B and T cells is strictly segregated throughout evolution. Here, we identified aberrant ZAP70 expression as a common feature in a broad range of B cell malignancies. We validated SYK as the kinase that sets the thresholds for negative selection of autoreactive and premalignant clones. When aberrantly expressed in B cells, ZAP70 competes with SYK at the BCR signalosome and redirects SYK from negative selection to tonic PI3K signaling, thereby promoting B cell survival. In genetic mouse models for B-ALL and B-CLL, conditional expression of Zap70 accelerated disease onset, while genetic deletion impaired malignant transformation. Inducible activation of Zap70 during B cell development compromised negative selection of autoreactive B cells, resulting in pervasive autoantibody production. Strict segregation of the two kinases is critical for normal B cell selection and represents a central safeguard against the development of autoimmune disease and B cell malignancies."xsd:string |
| http://purl.uniprot.org/citations/33878293 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2021.03.043"xsd:string |
| http://purl.uniprot.org/citations/33878293 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/33878293 | http://purl.uniprot.org/core/author | "Martin M."xsd:string |
| http://purl.uniprot.org/citations/33878293 | http://purl.uniprot.org/core/author | "Pandey A."xsd:string |
| http://purl.uniprot.org/citations/33878293 | http://purl.uniprot.org/core/author | "Heisterkamp N."xsd:string |
| http://purl.uniprot.org/citations/33878293 | http://purl.uniprot.org/core/author | "Song J.Y."xsd:string |
| http://purl.uniprot.org/citations/33878293 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/33878293 | http://purl.uniprot.org/core/author | "Martin T."xsd:string |
| http://purl.uniprot.org/citations/33878293 | http://purl.uniprot.org/core/author | "Kiefer F."xsd:string |
| http://purl.uniprot.org/citations/33878293 | http://purl.uniprot.org/core/author | "Meffre E."xsd:string |
| http://purl.uniprot.org/citations/33878293 | http://purl.uniprot.org/core/author | "Ruland J."xsd:string |
| http://purl.uniprot.org/citations/33878293 | http://purl.uniprot.org/core/author | "Chan W.C."xsd:string |
| http://purl.uniprot.org/citations/33878293 | http://purl.uniprot.org/core/author | "Jumaa H."xsd:string |
| http://purl.uniprot.org/citations/33878293 | http://purl.uniprot.org/core/author | "Muschen M."xsd:string |
| http://purl.uniprot.org/citations/33878293 | http://purl.uniprot.org/core/author | "Kume K."xsd:string |
| http://purl.uniprot.org/citations/33878293 | http://purl.uniprot.org/core/author | "Ngo V."xsd:string |
| http://purl.uniprot.org/citations/33878293 | http://purl.uniprot.org/core/author | "Cutler J."xsd:string |
| http://purl.uniprot.org/citations/33878293 | http://purl.uniprot.org/core/author | "Lenz G."xsd:string |
| http://purl.uniprot.org/citations/33878293 | http://purl.uniprot.org/core/author | "Knapp A.M."xsd:string |
| http://purl.uniprot.org/citations/33878293 | http://purl.uniprot.org/core/author | "Robinson M.E."xsd:string |
| http://purl.uniprot.org/citations/33878293 | http://purl.uniprot.org/core/author | "Soulas-Sprauel P."xsd:string |
| http://purl.uniprot.org/citations/33878293 | http://purl.uniprot.org/core/author | "Klemm L."xsd:string |
| http://purl.uniprot.org/citations/33878293 | http://purl.uniprot.org/core/author | "Siddiqi T."xsd:string |