| http://purl.uniprot.org/citations/33882275 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33882275 | http://www.w3.org/2000/01/rdf-schema#comment | "Wolbachia are common intracellular endosymbionts of arthropods, but the interactions between Wolbachia and arthropods are only partially understood. The fruit fly Drosophila melanogaster is a model insect for understanding Wolbachia-host interactions. Here the native wMel strain of D. melanogaster was isolated and then different initial titres of wMel were artificially transferred back into antibiotics-treated fruit flies. Our purpose was to examine the interactions between the injected wMel in a density gradient and the recipient host during trans-generational transmission. The results showed that the trans-generational transmission rates of wMel and titres of wMel exhibited a fluctuating trend over nine generations, and the titres of wMel displayed a similar fluctuating trans-generational trend. There was a significant positive correlation between the transmission rate and the titre of wMel. Reciprocal crossings between wMel-transinfected and uninfected fruit flies revealed that wMel could induce cytoplasmic incompatibility (CI) at different initial titres, but the intensity of CI was not significantly correlated with the initial titre of wMel. Quantitative PCR analysis showed that the immune genes Drsl5 and Spn38F displayed a significant transcriptional response to wMel transfection, with an obvious negative correlation with the titre of wMel at the 3rd and 4th generations. Furthermore, RNA interference-mediated knockdown of Drsl5 and Spn38F elicited a drastic increase in the titre of wMel. In combination, our study suggests that the trans-generational transmission of wMel is modulated by its density, and the immune genes are involved in the regulation of Wolbachia density."xsd:string |
| http://purl.uniprot.org/citations/33882275 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jip.2021.107591"xsd:string |
| http://purl.uniprot.org/citations/33882275 | http://purl.uniprot.org/core/author | "Li Z.X."xsd:string |
| http://purl.uniprot.org/citations/33882275 | http://purl.uniprot.org/core/author | "Liu X.C."xsd:string |
| http://purl.uniprot.org/citations/33882275 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33882275 | http://purl.uniprot.org/core/name | "J Invertebr Pathol"xsd:string |
| http://purl.uniprot.org/citations/33882275 | http://purl.uniprot.org/core/pages | "107591"xsd:string |
| http://purl.uniprot.org/citations/33882275 | http://purl.uniprot.org/core/title | "Transmission of the wMel Wolbachia strain is modulated by its titre and by immune genes in Drosophila melanogaster (Wolbachia density and transmission)."xsd:string |
| http://purl.uniprot.org/citations/33882275 | http://purl.uniprot.org/core/volume | "181"xsd:string |
| http://purl.uniprot.org/citations/33882275 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33882275 |
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| http://purl.uniprot.org/uniprot/#_P41964-mappedCitation-33882275 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33882275 |
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| http://purl.uniprot.org/uniprot/#_Q2UYN1-mappedCitation-33882275 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33882275 |
| http://purl.uniprot.org/uniprot/#_Q8IQR7-mappedCitation-33882275 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33882275 |