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http://purl.uniprot.org/citations/33886495http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/33886495http://www.w3.org/2000/01/rdf-schema#comment"

Objective

The insulinotropic effect of exogenous, intravenously infused glucose-dependent insulinotropic polypeptide (GIP) is impaired in patients with type 2 diabetes. We evaluated the effects of endogenous GIP in relation to glucose and bone metabolism in patients with type 2 diabetes using a selective GIP receptor antagonist and hypothesized that the effects of endogenous GIP were preserved.

Design

A randomized, double-blinded, placebo-controlled, crossover study.

Methods

Ten patients with overweight/obesity and type 2 diabetes (mean±s.d.; HbA1c 52 ± 11 mmol/mol; BMI 32.5 ± 4.8 kg/m2) were included. We infused a selective GIP receptor antagonist, GIP(3-30)NH2 (1200 pmol/kg/min), or placebo (saline) during two separate, 230-min, standardized, liquid mixed meal tests followed by a meal ad libitum. Subcutaneous adipose tissue biopsies were analyzed.

Results

Compared with placebo, GIP(3-30)NH2 reduced postprandial insulin secretion (Δbaseline-subtracted area under the curve (bsAUC)C-peptide% ± s.e.m.; -14 ± 6%, P = 0.021) and peak glucagon (Δ% ± s.e.m.; -11 ± 6%, P = 0.046) but had no effect on plasma glucose (P = 0.692). Suppression of bone resorption (assessed by circulating carboxy-terminal collagen crosslinks (CTX)) was impaired during GIP(3-30)NH2 infusion compared with placebo (ΔbsAUCCTX; ±s.e.m.; -4.9 ± 2 ng/mL × min, P = 0.005) corresponding to a ~50% reduction. Compared with placebo, GIP(3-30)NH2 did not affect plasma lipids, meal consumption ad libitum or adipose tissue triglyceride content.

Conclusions

Using a selective GIP receptor antagonist during a meal, we show that endogenous GIP increases postprandial insulin secretion with little effect on postprandial glycaemia but is important for postprandial bone homeostasis in patients with type 2 diabetes."xsd:string
http://purl.uniprot.org/citations/33886495http://purl.org/dc/terms/identifier"doi:10.1530/eje-21-0135"xsd:string
http://purl.uniprot.org/citations/33886495http://purl.uniprot.org/core/author"Jensen M.H."xsd:string
http://purl.uniprot.org/citations/33886495http://purl.uniprot.org/core/author"Rosenkilde M.M."xsd:string
http://purl.uniprot.org/citations/33886495http://purl.uniprot.org/core/author"Holst J.J."xsd:string
http://purl.uniprot.org/citations/33886495http://purl.uniprot.org/core/author"Hartmann B."xsd:string
http://purl.uniprot.org/citations/33886495http://purl.uniprot.org/core/author"Christensen M.B."xsd:string
http://purl.uniprot.org/citations/33886495http://purl.uniprot.org/core/author"Knop F.K."xsd:string
http://purl.uniprot.org/citations/33886495http://purl.uniprot.org/core/author"Sparre-Ulrich A.H."xsd:string
http://purl.uniprot.org/citations/33886495http://purl.uniprot.org/core/author"Vilsboll T."xsd:string
http://purl.uniprot.org/citations/33886495http://purl.uniprot.org/core/author"Dela F."xsd:string
http://purl.uniprot.org/citations/33886495http://purl.uniprot.org/core/author"Gasbjerg L.S."xsd:string
http://purl.uniprot.org/citations/33886495http://purl.uniprot.org/core/author"Krogh L.L."xsd:string
http://purl.uniprot.org/citations/33886495http://purl.uniprot.org/core/author"Skov-Jeppesen K."xsd:string
http://purl.uniprot.org/citations/33886495http://purl.uniprot.org/core/author"Stensen S."xsd:string
http://purl.uniprot.org/citations/33886495http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/33886495http://purl.uniprot.org/core/name"Eur J Endocrinol"xsd:string
http://purl.uniprot.org/citations/33886495http://purl.uniprot.org/core/pages"33-45"xsd:string
http://purl.uniprot.org/citations/33886495http://purl.uniprot.org/core/title"Effects of endogenous GIP in patients with type 2 diabetes."xsd:string
http://purl.uniprot.org/citations/33886495http://purl.uniprot.org/core/volume"185"xsd:string
http://purl.uniprot.org/citations/33886495http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/33886495
http://purl.uniprot.org/citations/33886495http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/33886495
http://purl.uniprot.org/uniprot/#_P09681-mappedCitation-33886495http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/33886495
http://purl.uniprot.org/uniprot/P09681http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/33886495
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