| http://purl.uniprot.org/citations/33900821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33900821 | http://www.w3.org/2000/01/rdf-schema#comment | "DNAM-1 is an activating immunoreceptor expressed on hematopoietic cells, including both CD4+ and CD8+ T cells, natural killer cells, and platelets. Since DNAM-1 is involved in the pathogenesis of various inflammatory diseases and cancers in humans as well as mouse models, it is a potential target for immunotherapy for these diseases. In this study, we generated a humanized neutralizing antihuman DNAM-1 monoclonal antibody (mAb), named TNAX101A, which contains an engineered Fc portion of human IgG1 to reduce Fc-mediated effector functions. We show that TNAX101A efficiently interfered the binding of DNAM-1 to its ligand CD155 and showed unique functions; it decreased production of the inflammatory cytokines such as interferon-gamma, tumor necrosis factor alpha, interleukin (IL)-6, IL-17A, and IL-17F by anti-CD3 antibody-stimulated or alloantigen-stimulated T cells and increased FOXP3 expression in anti-CD3-stimulated regulatory T (Treg) cells. These dual functions of TNAX101A may be advantageous for the treatment of T cell-mediated inflammatory diseases through both downregulation of effector T cell function and upregulation of Treg cell function."xsd:string |
| http://purl.uniprot.org/citations/33900821 | http://purl.org/dc/terms/identifier | "doi:10.1089/mab.2020.0042"xsd:string |
| http://purl.uniprot.org/citations/33900821 | http://purl.uniprot.org/core/author | "Shibuya K."xsd:string |
| http://purl.uniprot.org/citations/33900821 | http://purl.uniprot.org/core/author | "Abe F."xsd:string |
| http://purl.uniprot.org/citations/33900821 | http://purl.uniprot.org/core/author | "Shibuya A."xsd:string |
| http://purl.uniprot.org/citations/33900821 | http://purl.uniprot.org/core/author | "Yamashita-Kanemaru Y."xsd:string |
| http://purl.uniprot.org/citations/33900821 | http://purl.uniprot.org/core/author | "Oh-Oka K."xsd:string |
| http://purl.uniprot.org/citations/33900821 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33900821 | http://purl.uniprot.org/core/name | "Monoclon Antib Immunodiagn Immunother"xsd:string |
| http://purl.uniprot.org/citations/33900821 | http://purl.uniprot.org/core/pages | "52-59"xsd:string |
| http://purl.uniprot.org/citations/33900821 | http://purl.uniprot.org/core/title | "Suppression of Th1 and Th17 Proinflammatory Cytokines and Upregulation of FOXP3 Expression by a Humanized Anti-DNAM-1 Monoclonal Antibody."xsd:string |
| http://purl.uniprot.org/citations/33900821 | http://purl.uniprot.org/core/volume | "40"xsd:string |
| http://purl.uniprot.org/citations/33900821 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33900821 |
| http://purl.uniprot.org/citations/33900821 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33900821 |
| http://purl.uniprot.org/uniprot/#_J3QR77-mappedCitation-33900821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33900821 |
| http://purl.uniprot.org/uniprot/#_Q15762-mappedCitation-33900821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33900821 |
| http://purl.uniprot.org/uniprot/Q15762 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33900821 |
| http://purl.uniprot.org/uniprot/J3QR77 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33900821 |