| http://purl.uniprot.org/citations/33903707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33903707 | http://www.w3.org/2000/01/rdf-schema#comment | "Nutritional status during gestation may lead to a phenomenon known as metabolic programming, which can be triggered by epigenetic mechanisms. The Let-7 family of microRNAs were one of the first to be discovered, and are closely related to metabolic processes. Bioinformatic analysis revealed that Prkaa2, the gene that encodes AMPK α2, is a predicted target of Let-7. Here we aimed to investigate whether Let-7 has a role in AMPKα2 levels in the NAFLD development in the offspring programmed by maternal obesity. Let-7 levels were upregulated in the liver of newborn mice from obese dams, while the levels of Prkaa2 were downregulated. Let-7 levels strongly correlated with serum glucose, insulin and NEFA, and in vitro treatment of AML12 with glucose and NEFA lead to higher Let-7 expression. Transfection of Let-7a mimic lead to downregulation of AMPKα2 levels, while the transfection with Let-7a inhibitor impaired both NEFA-mediated reduction of Prkaa2 levels and the fat accumulation driven by NEFA. The transfection of Let-7a inhibitor in ex-vivo liver slices from the offspring of obese dams restored phospho-AMPKα2 levels. In summary, Let-7a appears to regulate hepatic AMPKα2 protein levels and lead to the early hepatic metabolic disturbances in the offspring of obese dams."xsd:string |
| http://purl.uniprot.org/citations/33903707 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-021-88518-8"xsd:string |
| http://purl.uniprot.org/citations/33903707 | http://purl.uniprot.org/core/author | "Desai M."xsd:string |
| http://purl.uniprot.org/citations/33903707 | http://purl.uniprot.org/core/author | "Fontana M.F."xsd:string |
| http://purl.uniprot.org/citations/33903707 | http://purl.uniprot.org/core/author | "Torsoni M.A."xsd:string |
| http://purl.uniprot.org/citations/33903707 | http://purl.uniprot.org/core/author | "Geraldo M.V."xsd:string |
| http://purl.uniprot.org/citations/33903707 | http://purl.uniprot.org/core/author | "Ross M.G."xsd:string |
| http://purl.uniprot.org/citations/33903707 | http://purl.uniprot.org/core/author | "Torsoni A.S."xsd:string |
| http://purl.uniprot.org/citations/33903707 | http://purl.uniprot.org/core/author | "Milanski M."xsd:string |
| http://purl.uniprot.org/citations/33903707 | http://purl.uniprot.org/core/author | "Ignacio-Souza L.M."xsd:string |
| http://purl.uniprot.org/citations/33903707 | http://purl.uniprot.org/core/author | "de Fante T."xsd:string |
| http://purl.uniprot.org/citations/33903707 | http://purl.uniprot.org/core/author | "Panzarin C."xsd:string |
| http://purl.uniprot.org/citations/33903707 | http://purl.uniprot.org/core/author | "Simino L.A.P."xsd:string |
| http://purl.uniprot.org/citations/33903707 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33903707 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/33903707 | http://purl.uniprot.org/core/pages | "8980"xsd:string |
| http://purl.uniprot.org/citations/33903707 | http://purl.uniprot.org/core/title | "MicroRNA Let-7 targets AMPK and impairs hepatic lipid metabolism in offspring of maternal obese pregnancies."xsd:string |
| http://purl.uniprot.org/citations/33903707 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/33903707 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33903707 |
| http://purl.uniprot.org/citations/33903707 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33903707 |
| http://purl.uniprot.org/uniprot/#_G8XUU5-mappedCitation-33903707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33903707 |
| http://purl.uniprot.org/uniprot/#_Q8BRK8-mappedCitation-33903707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33903707 |
| http://purl.uniprot.org/uniprot/Q8BRK8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33903707 |
| http://purl.uniprot.org/uniprot/G8XUU5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33903707 |