| http://purl.uniprot.org/citations/33903974 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33903974 | http://www.w3.org/2000/01/rdf-schema#comment | "Immune checkpoint inhibitors (ICIs) have emerged as promising therapies for the treatment of cancer. However, existing ICIs, namely PD-(L)1 and CTLA-4 inhibitors, generate durable responses only in a subset of patients. TIGIT is a co-inhibitory receptor and member of the DNAM-1 family of immune modulating proteins. We evaluated the prevalence of TIGIT and its cognate ligand, PVR (CD155), in human cancers by assessing their expression in a large set of solid tumors. TIGIT is expressed on CD4+ and CD8+ TILs and is upregulated in tumors compared to normal tissues. PVR is expressed on tumor cells and tumor-associated macrophages from multiple solid tumors. We explored the therapeutic potential of targeting TIGIT by generating COM902, a fully human anti-TIGIT hinge-stabilized IgG4 monoclonal antibody that binds specifically to human, cynomolgus monkey, and mouse TIGIT, and disrupts the binding of TIGIT with PVR. COM902, either alone or in combination with a PVRIG (COM701) or PD-1 inhibitor, enhances antigen-specific human T cell responses in-vitro. In-vivo, a mouse chimeric version of COM902 in combination with an anti-PVRIG or anti-PD-L1 antibody inhibited tumor growth and increased survival in two syngeneic mouse tumor models. In summary, COM902 enhances anti-tumor immune responses and is a promising candidate for the treatment of advanced malignancies."xsd:string |
| http://purl.uniprot.org/citations/33903974 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00262-021-02921-8"xsd:string |
| http://purl.uniprot.org/citations/33903974 | http://purl.uniprot.org/core/author | "Hansen K."xsd:string |
| http://purl.uniprot.org/citations/33903974 | http://purl.uniprot.org/core/author | "Kumar S."xsd:string |
| http://purl.uniprot.org/citations/33903974 | http://purl.uniprot.org/core/author | "Tang M."xsd:string |
| http://purl.uniprot.org/citations/33903974 | http://purl.uniprot.org/core/author | "Galperin M."xsd:string |
| http://purl.uniprot.org/citations/33903974 | http://purl.uniprot.org/core/author | "White M."xsd:string |
| http://purl.uniprot.org/citations/33903974 | http://purl.uniprot.org/core/author | "Liang S.C."xsd:string |
| http://purl.uniprot.org/citations/33903974 | http://purl.uniprot.org/core/author | "Cheng H.Y."xsd:string |
| http://purl.uniprot.org/citations/33903974 | http://purl.uniprot.org/core/author | "Cojocaru G."xsd:string |
| http://purl.uniprot.org/citations/33903974 | http://purl.uniprot.org/core/author | "Leung L."xsd:string |
| http://purl.uniprot.org/citations/33903974 | http://purl.uniprot.org/core/author | "Hunter J."xsd:string |
| http://purl.uniprot.org/citations/33903974 | http://purl.uniprot.org/core/author | "Whelan S."xsd:string |
| http://purl.uniprot.org/citations/33903974 | http://purl.uniprot.org/core/author | "Wall P."xsd:string |
| http://purl.uniprot.org/citations/33903974 | http://purl.uniprot.org/core/author | "Drake A."xsd:string |
| http://purl.uniprot.org/citations/33903974 | http://purl.uniprot.org/core/author | "Kotturi M.F."xsd:string |
| http://purl.uniprot.org/citations/33903974 | http://purl.uniprot.org/core/author | "Qurashi S."xsd:string |
| http://purl.uniprot.org/citations/33903974 | http://purl.uniprot.org/core/author | "Frenkel M."xsd:string |
| http://purl.uniprot.org/citations/33903974 | http://purl.uniprot.org/core/author | "Ophir E."xsd:string |
| http://purl.uniprot.org/citations/33903974 | http://purl.uniprot.org/core/author | "Logronio K."xsd:string |
| http://purl.uniprot.org/citations/33903974 | http://purl.uniprot.org/core/author | "Alteber Z."xsd:string |
| http://purl.uniprot.org/citations/33903974 | http://purl.uniprot.org/core/author | "Bernados D."xsd:string |
| http://purl.uniprot.org/citations/33903974 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33903974 | http://purl.uniprot.org/core/name | "Cancer Immunol Immunother"xsd:string |