| http://purl.uniprot.org/citations/33913550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33913550 | http://www.w3.org/2000/01/rdf-schema#comment | "The suppression of types I and III interferon (IFN) responses by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contributes to the pathogenesis of coronavirus disease 2019 (COVID-19). The strategy used by SARS-CoV-2 to evade antiviral immunity needs further investigation. Here, we reported that SARS-CoV-2 ORF9b inhibited types I and III IFN production by targeting multiple molecules of innate antiviral signaling pathways. SARS-CoV-2 ORF9b impaired the induction of types I and III IFNs by Sendai virus and poly (I:C). SARS-CoV-2 ORF9b inhibited the activation of types I and III IFNs induced by the components of cytosolic dsRNA-sensing pathways of RIG-I/MDA5-MAVS signaling, including RIG-I, MDA-5, MAVS, TBK1, and IKKε, rather than IRF3-5D, which is the active form of IRF3. SARS-CoV-2 ORF9b also suppressed the induction of types I and III IFNs by TRIF and STING, which are the adaptor protein of the endosome RNA-sensing pathway of TLR3-TRIF signaling and the adaptor protein of the cytosolic DNA-sensing pathway of cGAS-STING signaling, respectively. A mechanistic analysis revealed that the SARS-CoV-2 ORF9b protein interacted with RIG-I, MDA-5, MAVS, TRIF, STING, and TBK1 and impeded the phosphorylation and nuclear translocation of IRF3. In addition, SARS-CoV-2 ORF9b facilitated the replication of the vesicular stomatitis virus. Therefore, the results showed that SARS-CoV-2 ORF9b negatively regulates antiviral immunity and thus facilitates viral replication. This study contributes to our understanding of the molecular mechanism through which SARS-CoV-2 impairs antiviral immunity and provides an essential clue to the pathogenesis of COVID-19."xsd:string |
| http://purl.uniprot.org/citations/33913550 | http://purl.org/dc/terms/identifier | "doi:10.1002/jmv.27050"xsd:string |
| http://purl.uniprot.org/citations/33913550 | http://purl.uniprot.org/core/author | "Gao C."xsd:string |
| http://purl.uniprot.org/citations/33913550 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/33913550 | http://purl.uniprot.org/core/author | "Zheng Y."xsd:string |
| http://purl.uniprot.org/citations/33913550 | http://purl.uniprot.org/core/author | "Wang P.H."xsd:string |
| http://purl.uniprot.org/citations/33913550 | http://purl.uniprot.org/core/author | "Deng J."xsd:string |
| http://purl.uniprot.org/citations/33913550 | http://purl.uniprot.org/core/author | "Han L."xsd:string |
| http://purl.uniprot.org/citations/33913550 | http://purl.uniprot.org/core/author | "Zhang X.J."xsd:string |
| http://purl.uniprot.org/citations/33913550 | http://purl.uniprot.org/core/author | "Zhuang M.W."xsd:string |
| http://purl.uniprot.org/citations/33913550 | http://purl.uniprot.org/core/author | "Nan M.L."xsd:string |
| http://purl.uniprot.org/citations/33913550 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33913550 | http://purl.uniprot.org/core/name | "J Med Virol"xsd:string |
| http://purl.uniprot.org/citations/33913550 | http://purl.uniprot.org/core/pages | "5376-5389"xsd:string |
| http://purl.uniprot.org/citations/33913550 | http://purl.uniprot.org/core/title | "SARS-CoV-2 ORF9b antagonizes type I and III interferons by targeting multiple components of the RIG-I/MDA-5-MAVS, TLR3-TRIF, and cGAS-STING signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/33913550 | http://purl.uniprot.org/core/volume | "93"xsd:string |
| http://purl.uniprot.org/citations/33913550 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33913550 |
| http://purl.uniprot.org/citations/33913550 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33913550 |
| http://purl.uniprot.org/uniprot/#_E2GIM5-mappedCitation-33913550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33913550 |
| http://purl.uniprot.org/uniprot/#_E2GIM6-mappedCitation-33913550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33913550 |
| http://purl.uniprot.org/uniprot/#_E2GIM7-mappedCitation-33913550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33913550 |
| http://purl.uniprot.org/uniprot/#_E2GIM8-mappedCitation-33913550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33913550 |
| http://purl.uniprot.org/uniprot/#_E2GIM9-mappedCitation-33913550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33913550 |
| http://purl.uniprot.org/uniprot/#_A0A2R3XZB7-mappedCitation-33913550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33913550 |