| http://purl.uniprot.org/citations/33919765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33919765 | http://www.w3.org/2000/01/rdf-schema#comment | "Although RAS family genes play essential roles in tumorigenesis, effective treatments targeting RAS-related tumors are lacking, partly because of an incomplete understanding of the complex signaling crosstalk within RAS-related tumors. Here, we performed a large-scale genetic screen in Drosophila eye imaginal discs and identified Misshapen (Msn) as a tumor suppressor that synergizes with oncogenic Ras (RasV12) to induce c-Jun N-terminal kinase (JNK) activation and Hippo inactivation, then subsequently leads to tumor overgrowth and invasion. Moreover, ectopic Msn expression activates Hippo signaling pathway and suppresses Hippo signaling disruption-induced overgrowth. Importantly, we further found that Msn acts downstream of protocadherin Fat (Ft) to regulate Hippo signaling. Finally, we identified msn as a Yki/Sd target gene that regulates Hippo pathway in a negative feedback manner. Together, our findings identified Msn as a tumor suppressor and provide a novel insight into RAS-related tumorigenesis that may be relevant to human cancer biology."xsd:string |
| http://purl.uniprot.org/citations/33919765 | http://purl.org/dc/terms/identifier | "doi:10.3390/cells10040894"xsd:string |
| http://purl.uniprot.org/citations/33919765 | http://purl.uniprot.org/core/author | "Fang J."xsd:string |
| http://purl.uniprot.org/citations/33919765 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/33919765 | http://purl.uniprot.org/core/author | "Ma X."xsd:string |
| http://purl.uniprot.org/citations/33919765 | http://purl.uniprot.org/core/author | "Xu W."xsd:string |
| http://purl.uniprot.org/citations/33919765 | http://purl.uniprot.org/core/author | "Zhao S."xsd:string |
| http://purl.uniprot.org/citations/33919765 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/33919765 | http://purl.uniprot.org/core/author | "Kong D."xsd:string |
| http://purl.uniprot.org/citations/33919765 | http://purl.uniprot.org/core/author | "Lu J.Y."xsd:string |
| http://purl.uniprot.org/citations/33919765 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33919765 | http://purl.uniprot.org/core/name | "Cells"xsd:string |
| http://purl.uniprot.org/citations/33919765 | http://purl.uniprot.org/core/pages | "894"xsd:string |
| http://purl.uniprot.org/citations/33919765 | http://purl.uniprot.org/core/title | "Misshapen Disruption Cooperates with RasV12 to Drive Tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/33919765 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/33919765 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33919765 |
| http://purl.uniprot.org/citations/33919765 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33919765 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHN3-mappedCitation-33919765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33919765 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DHD4-mappedCitation-33919765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33919765 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHY2-mappedCitation-33919765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33919765 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KI37-mappedCitation-33919765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33919765 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K6M4-mappedCitation-33919765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33919765 |
| http://purl.uniprot.org/uniprot/#_E1JHD6-mappedCitation-33919765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33919765 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K7W1-mappedCitation-33919765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33919765 |