| http://purl.uniprot.org/citations/33923443 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33923443 | http://www.w3.org/2000/01/rdf-schema#comment | "During cell migration, protrusion of the leading edge is driven by the polymerization of Arp2/3-dependent branched actin networks. Migration persistence is negatively regulated by the Arp2/3 inhibitory protein Arpin. To better understand Arpin regulation in the cell, we looked for its interacting partners and identified both Tankyrase 1 and 2 (TNKS) using a yeast two-hybrid screening and coimmunoprecipitation with full-length Arpin as bait. Arpin interacts with ankyrin repeats of TNKS through a C-terminal-binding site on its acidic tail, which overlaps with the Arp2/3-binding site. Arpin was found to dissolve the liquid-liquid phase separation of TNKS upon overexpression. To uncouple the interactions of Arpin with TNKS and Arp2/3, we introduced point mutations in the Arpin tail and attempted to rescue the increased migration persistence of the Arpin knockout cells using random plasmid integration or compensating knock-ins at the ARPIN locus. Arpin mutations impairing interactions with either Arp2/3 or TNKS were insufficient to fully abolish Arpin activity. Only the mutation that affected both interactions rendered Arpin completely inactive, suggesting the existence of two independent pathways, whereby Arpin controls the migration persistence."xsd:string |
| http://purl.uniprot.org/citations/33923443 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms22084115"xsd:string |
| http://purl.uniprot.org/citations/33923443 | http://purl.uniprot.org/core/author | "Campanacci V."xsd:string |
| http://purl.uniprot.org/citations/33923443 | http://purl.uniprot.org/core/author | "Cherfils J."xsd:string |
| http://purl.uniprot.org/citations/33923443 | http://purl.uniprot.org/core/author | "Dang I."xsd:string |
| http://purl.uniprot.org/citations/33923443 | http://purl.uniprot.org/core/author | "Oguievetskaia K."xsd:string |
| http://purl.uniprot.org/citations/33923443 | http://purl.uniprot.org/core/author | "Fokin A.I."xsd:string |
| http://purl.uniprot.org/citations/33923443 | http://purl.uniprot.org/core/author | "Gautreau A.M."xsd:string |
| http://purl.uniprot.org/citations/33923443 | http://purl.uniprot.org/core/author | "Simanov G."xsd:string |
| http://purl.uniprot.org/citations/33923443 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33923443 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/33923443 | http://purl.uniprot.org/core/pages | "4115"xsd:string |
| http://purl.uniprot.org/citations/33923443 | http://purl.uniprot.org/core/title | "Arpin Regulates Migration Persistence by Interacting with Both Tankyrases and the Arp2/3 Complex."xsd:string |
| http://purl.uniprot.org/citations/33923443 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/33923443 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33923443 |
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