| http://purl.uniprot.org/citations/33931183 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33931183 | http://www.w3.org/2000/01/rdf-schema#comment | "Neurotransmission of acoustic signals from the hair cells to the auditory nerve relies on a tightly controlled communication between pre-synaptic ribbons and post-synaptic glutamatergic terminals. After noise overexposure, de-afferentation occurs as a consequence of excessive glutamate release. What maintains synaptic integrity in the cochlea is poorly understood. The objective of this study is to evaluate the role of GLAST in maintaining synaptic integrity in the cochlea in absence or presence of noise, and its impact on sound-evoked brain activity using manganese-enhanced MRI (MeMRI). The glutamate aspartate transporter GLAST is present in supporting cells near the afferent synapse and its genetic deletion leads to greater synaptic swelling after noise overexposure. At baseline, GLAST knockout (GLAST KO) mice displayed two-fold lower wave 1 amplitude of the auditory brainstem response (ABR) when compared to their wild-type littermates in spite of similar ABR and distortion product otoacoustic emissions (DPOAE) thresholds. While the abundance of ribbons was not affected by the loss of GLAST function, the number of paired synapses was halved in GLAST KO mice, suggestive of a pre-existing auditory synaptopathy. Immediately after the noise exposure ABR thresholds rose by 41-62dB to a similar degree in GLAST WT and KO mice and DPOAE remained unaffected. In the acute phase following noise exposure, GLAST KO mice showed near complete de-afferentation unlike WT mice which maintained four to seven paired synapses per IHC. Brain activity using MeMRI found noise exposure to cause greater activity in the inferior colliculus in GLAST KO but not in WT mice. No changes in brain activity was found in GLAST KO mice at baseline in spite of affected afferent synapses, suggesting that auditory synaptopathy may not be sufficient to alter brain activity in the absence of noise exposure."xsd:string |
| http://purl.uniprot.org/citations/33931183 | http://purl.org/dc/terms/identifier | "doi:10.1016/bs.pbr.2020.04.004"xsd:string |
| http://purl.uniprot.org/citations/33931183 | http://purl.uniprot.org/core/author | "Canlon B."xsd:string |
| http://purl.uniprot.org/citations/33931183 | http://purl.uniprot.org/core/author | "Damberg P."xsd:string |
| http://purl.uniprot.org/citations/33931183 | http://purl.uniprot.org/core/author | "Cederroth C.R."xsd:string |
| http://purl.uniprot.org/citations/33931183 | http://purl.uniprot.org/core/author | "Tserga E."xsd:string |
| http://purl.uniprot.org/citations/33931183 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33931183 | http://purl.uniprot.org/core/name | "Prog Brain Res"xsd:string |
| http://purl.uniprot.org/citations/33931183 | http://purl.uniprot.org/core/pages | "245-261"xsd:string |
| http://purl.uniprot.org/citations/33931183 | http://purl.uniprot.org/core/title | "Auditory synaptopathy in mice lacking the glutamate transporter GLAST and its impact on brain activity."xsd:string |
| http://purl.uniprot.org/citations/33931183 | http://purl.uniprot.org/core/volume | "262"xsd:string |
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