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http://purl.uniprot.org/citations/33935285http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/33935285http://www.w3.org/2000/01/rdf-schema#comment"

Objective

Metabolic disturbance of lysophosphatidylcholine (LPC) is related with dyslipidemia. Therefore, eight single-nucleotide polymorphisms (SNPs) were selected from LPC metabolic enzymes to study their associations with obesity and serum levels of lipids.

Methods

A total of 3305 children were recruited from four independent studies. Eight SNPs of LPC metabolic enzymes were selected and genotyped with the matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS). The multivariable linear regression model was applied to detect the associations of eight SNPs with obesity-related phenotypes and levels of lipids in each study. Meta-analyses were used to combine the results of four studies.

Results

Only SNP rs4420638 of APOC-1 gene was associated with serum lipids even after Bonferroni correction. The rs4420638 was positively associated with TC (β = 0.15, P = 8.59 × 10-9) and low-density-lipoprotein-cholesterol (LDL-C, β = 0.16, P = 9.98 × 10-14) individually.

Conclusion

The study firstly revealed the association between APOC-1/rs4420638 and levels of serum lipids in Chinese children, providing evidence for susceptible gene variants of dyslipidemia."xsd:string
http://purl.uniprot.org/citations/33935285http://purl.org/dc/terms/identifier"doi:10.1038/s41390-021-01549-9"xsd:string
http://purl.uniprot.org/citations/33935285http://purl.uniprot.org/core/author"Li L."xsd:string
http://purl.uniprot.org/citations/33935285http://purl.uniprot.org/core/author"Song J.Y."xsd:string
http://purl.uniprot.org/citations/33935285http://purl.uniprot.org/core/author"Wang Y."xsd:string
http://purl.uniprot.org/citations/33935285http://purl.uniprot.org/core/author"Wang H."xsd:string
http://purl.uniprot.org/citations/33935285http://purl.uniprot.org/core/author"Wang H.J."xsd:string
http://purl.uniprot.org/citations/33935285http://purl.uniprot.org/core/author"Li C.X."xsd:string
http://purl.uniprot.org/citations/33935285http://purl.uniprot.org/core/author"Zhang P.P."xsd:string
http://purl.uniprot.org/citations/33935285http://purl.uniprot.org/core/author"Song Q.Y."xsd:string
http://purl.uniprot.org/citations/33935285http://purl.uniprot.org/core/date"2022"xsd:gYear
http://purl.uniprot.org/citations/33935285http://purl.uniprot.org/core/name"Pediatr Res"xsd:string
http://purl.uniprot.org/citations/33935285http://purl.uniprot.org/core/pages"1595-1599"xsd:string
http://purl.uniprot.org/citations/33935285http://purl.uniprot.org/core/title"Associations of genetic variants of lysophosphatidylcholine metabolic enzymes with levels of serum lipids."xsd:string
http://purl.uniprot.org/citations/33935285http://purl.uniprot.org/core/volume"91"xsd:string
http://purl.uniprot.org/citations/33935285http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/33935285
http://purl.uniprot.org/citations/33935285http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/33935285
http://purl.uniprot.org/uniprot/#_P02654-mappedCitation-33935285http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/33935285
http://purl.uniprot.org/uniprot/P02654http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/33935285