| http://purl.uniprot.org/citations/33940385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33940385 | http://www.w3.org/2000/01/rdf-schema#comment | "Diabetic nephropathy (DN) is the primary cause of end-stage renal disease, and renal tubular cell dysfunction contributes to the pathogenesis of many kidney diseases. Our previous study demonstrated that dual-specificity protein phosphatase 1 (DUSP1) reduced hyperglycemia-mediated mitochondrial damage; however, its role in hyperglycemia-driven dysfunction of tubular cells is still not fully understood. In this study, we found that DUSP1 is reduced in human proximal tubular epithelial (HK-2) cells under high-glucose conditions. DUSP1 overexpression in HK-2 cells partially restored autophagic flux, improved mitochondrial function, and reduced reactive oxygen species generation and cell apoptosis under high-glucose conditions. Surprisingly, overexpressing DUSP1 abolished the decrease in mitochondrial parkin expression caused by high-glucose stimulation. In addition, knockdown of parkin in HK-2 cells reversed the effects of DUSP1 overexpression on mitophagy and apoptosis under high-glucose conditions. Overall, these data indicate that DUSP1 plays a defensive role in the pathogenesis of DN by restoring parkin-mediated mitophagy, suggesting that it may be considered a prospective therapeutic strategy for the amelioration of DN."xsd:string |
| http://purl.uniprot.org/citations/33940385 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2021.04.032"xsd:string |
| http://purl.uniprot.org/citations/33940385 | http://purl.uniprot.org/core/author | "Lu C."xsd:string |
| http://purl.uniprot.org/citations/33940385 | http://purl.uniprot.org/core/author | "Wu B."xsd:string |
| http://purl.uniprot.org/citations/33940385 | http://purl.uniprot.org/core/author | "Feng J."xsd:string |
| http://purl.uniprot.org/citations/33940385 | http://purl.uniprot.org/core/author | "Sheng J."xsd:string |
| http://purl.uniprot.org/citations/33940385 | http://purl.uniprot.org/core/author | "Liao Z."xsd:string |
| http://purl.uniprot.org/citations/33940385 | http://purl.uniprot.org/core/author | "Xue M."xsd:string |
| http://purl.uniprot.org/citations/33940385 | http://purl.uniprot.org/core/author | "Zou Z."xsd:string |
| http://purl.uniprot.org/citations/33940385 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33940385 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/33940385 | http://purl.uniprot.org/core/pages | "141-147"xsd:string |
| http://purl.uniprot.org/citations/33940385 | http://purl.uniprot.org/core/title | "DUSP1 overexpression attenuates renal tubular mitochondrial dysfunction by restoring Parkin-mediated mitophagy in diabetic nephropathy."xsd:string |
| http://purl.uniprot.org/citations/33940385 | http://purl.uniprot.org/core/volume | "559"xsd:string |
| http://purl.uniprot.org/citations/33940385 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33940385 |
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