| http://purl.uniprot.org/citations/33950834 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33950834 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33950834 | http://www.w3.org/2000/01/rdf-schema#comment | "Neural circuits develop through a plastic phase orchestrated by genetic programs and environmental signals. We have identified a leucine-rich-repeat domain transmembrane protein PAN-1 as a factor required for synaptic rewiring in C. elegans. PAN-1 localizes on cell membrane and binds with MYRF, a membrane-bound transcription factor indispensable for promoting synaptic rewiring. Full-length MYRF was known to undergo self-cleavage on ER membrane and release its transcriptional N-terminal fragment in cultured cells. We surprisingly find that MYRF trafficking to cell membrane before cleavage is pivotal for C. elegans development and the timing of N-MYRF release coincides with the onset of synaptic rewiring. On cell membrane PAN-1 and MYRF interact with each other via their extracellular regions. Loss of PAN-1 abolishes MYRF cell membrane localization, consequently blocking myrf-dependent neuronal rewiring process. Thus, through interactions with a cooperating factor on the cell membrane, MYRF may link cell surface activities to transcriptional cascades required for development."xsd:string |
| http://purl.uniprot.org/citations/33950834 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.67628"xsd:string |
| http://purl.uniprot.org/citations/33950834 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.67628"xsd:string |
| http://purl.uniprot.org/citations/33950834 | http://purl.uniprot.org/core/author | "Chen B."xsd:string |
| http://purl.uniprot.org/citations/33950834 | http://purl.uniprot.org/core/author | "Chen B."xsd:string |
| http://purl.uniprot.org/citations/33950834 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/33950834 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/33950834 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/33950834 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/33950834 | http://purl.uniprot.org/core/author | "Dong M.Q."xsd:string |
| http://purl.uniprot.org/citations/33950834 | http://purl.uniprot.org/core/author | "Dong M.Q."xsd:string |
| http://purl.uniprot.org/citations/33950834 | http://purl.uniprot.org/core/author | "Qi Y.B."xsd:string |
| http://purl.uniprot.org/citations/33950834 | http://purl.uniprot.org/core/author | "Qi Y.B."xsd:string |
| http://purl.uniprot.org/citations/33950834 | http://purl.uniprot.org/core/author | "Yan Y.H."xsd:string |
| http://purl.uniprot.org/citations/33950834 | http://purl.uniprot.org/core/author | "Yan Y.H."xsd:string |
| http://purl.uniprot.org/citations/33950834 | http://purl.uniprot.org/core/author | "Xia S.L."xsd:string |
| http://purl.uniprot.org/citations/33950834 | http://purl.uniprot.org/core/author | "Xia S.L."xsd:string |
| http://purl.uniprot.org/citations/33950834 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33950834 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33950834 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/33950834 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/33950834 | http://purl.uniprot.org/core/title | "The LRR-TM protein PAN-1 interacts with MYRF to promote its nuclear translocation in synaptic remodeling."xsd:string |
| http://purl.uniprot.org/citations/33950834 | http://purl.uniprot.org/core/title | "The LRR-TM protein PAN-1 interacts with MYRF to promote its nuclear translocation in synaptic remodeling."xsd:string |